Background: Ichthyoses are genetic disorders of keratinization which are uncomfortable due to their conspicuous scaling, itching and cosmetic problems. Especially in childhood, ichthyoses can lead to social discrimination and psychological problems. Efficient therapies are necessary which are safe and well tolerated. Objective: The aim of the study was to investigate the keratolytic and moisterurizing properties as well as the tolerance of a new urea lotion when applied to hyperkeratotic and ichthyotic skin in childhood. Methods: The study was conducted as a multicenter, randomized, placebo-controlled, double-blind, semilateral investigation. Sixty children between 1 and 16 years treated one side of the most affected extremity with Laceran 10% urea lotion for 8 weeks. On the other side the urea-free Laceran lotion base was given. On each side of the body a control area was left untreated. The investigators evaluated the global severity of ichthyotic symptoms with the help of a visual analogue scale. Results: The analysis of the global estimation of severity of ichthyosis showed improvements being stronger in the body areas treated with Laceran 10% urea lotion (from 4.8 to 2.0 points) than in the areas treated with the urea-free Laceran lotion base (from 4.8 to 2.5 points). The response rates were 65% after 4 weeks and 78% after 8 weeks for Laceran 10% urea lotion, 50% after 4 weeks and 72% after 8 weeks for the urea-free Laceran lotion base. Conclusion: It can be ascertained that Laceran 10% urea lotion has a strong positive effect on generalized ichthyotic keratinization disorders.

1.
Traupe H: The Ichthyoses. A Guide to Clinical Diagnosis, Genetic Counselling, and Therapy. Berlin, Springer, 1988.
2.
Serup J: Urea revisited. Including clinical uses and evaluation by bioengineering techniques. Acta Derm Venereol (Stockh) Suppl 1992;177: 5–6.
3.
Desu MM, Raghavarao D: Sample Size Methodology. Boston, Academic Press, 1990.
4.
Swanbeck G: Urea in the treatment of dry skin. Acta Derm Venereol (Stockh) Suppl 1992;177: 7–8.
5.
Serup J: A double-blind comparison of two creams containing urea as the active ingredient. Acta Derm Venereol (Stockh) Suppl 1992; 177:34–38.
6.
Van Scott EJ, Yu RJ: Control of keratinization with α-hydroxy acids and related compounds. Topical treatment of ichthyotic disorders. Arch Dermatol 1974;110:586–590.
7.
Swanbeck G: A new treatment of ichthyosis and other hyperkeratotic conditions. Acta Derm Venereol (Stockh) 1968;48:123–127.
8.
Grice K, Sattar H, Baker H: Urea and retinoic acid in ichthyosis and their effect on transepidermal water loss and water holding capacity of stratum corneum. Acta Derm Venereol (Stockh) 1973;53:114–118.
9.
Beverley DW, Wheeler D: High plasma urea concentrations in collodion babies. Arch Dis Child 1986;61:696–698.
10.
Garty BZ: High plasma urea concentrations in babies with lamellar ichthyosis (letter). Arch Dis Child 1986;61:1245–1246.
11.
Rasmussen JE: Percutaneous absorption in children; in Dobson RL (ed): Year Book of Dermatology 1979. Chicago, Year Book Medical Publishers, 1979, pp 15–38.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.