The purpose of this study was to investigate the possible role of reactive oxygen species (ROS) generated by neutrophils in mediating acne inflammation. Antibiotics used for the treatment of acne significantly inhibited ROS generated by neutrophils, when compared to other antibiotics. Metronidazole, which is effective in the treatment of acne, markedly inhibited ROS generated by neutrophils. The drug is known to have no significant effect on the growth of Propionibacterium acnes. The proportion of linoleic acid is markedly decreased in acne comedones. Linoleic acid significantly suppressed ROS generated by neutrophils. The ability of neutrophils to produce ROS was significantly increased in patients with acne inflammation. These results seem to reveal the involvement of ROS generated by neutrophils in the disruption of the integrity of the follicular epithelium, which is responsible for inflammatory processes of acne.

Pochi PE: Acne: Androgens and microbiology. Drug Dev Res 1988;13:157–168.
Sedgwick JB, Bergstresser PR, Hurd ER: Increased superoxide generation by normal granulocytes incubated in sera from patients with psoriasis. J Invest Dermatol 1981;76:158–163.
Niwa Y, Miyake S, Sakane T, Shingu M, Yokoyama M: Auto-oxidative damage in Behçet’s disease – Endothelial cell damage following the elevated oxygen radicals generated by stimulated neutrophils. Clin Exp Immunol 1982;49:247–255.
Pye RJ, Burton JL: Treatment of rosacea by metronidazole. Lancet 1976;i:1211–1215.
Miyachi Y, Imamura S, Niwa Y: Anti-oxidant action of metronidazole: A possible mechanism of action of rosacea. Br J Dermatol 1986; 114:231–234.
Akamatsu H, Oguchi M, Nishijima S, Asada Y, Takahashi M, Ushijima T, Niwa Y: The inhibition of free radical generation by human neutrophils through the synergistic effects of metronidazole with palmitoleic acid: A possible mechanism of action of metronidazole in rosacea and acne. Arch Dermatol Res 1990; 282:449–454.
Oguchi M, Akamatsu H, Asada M, Kubo K, Namura S, Shirai K, Asada Y, Nishijima S: Treatment of acne with oral metronidazole. Skin Res 1987;29:995–1000.
Perisho K, Wertz PW, Madison KC, Stewart ME, Downing DT: Fatty acids of acylceramides from comedones and from the skin surface of acne patients and control subjects. J Invest Dermatol 1988;90:350–353.
Akamatsu H, Komura J, Miyachi Y, Asada Y, Niwa Y: Suppressive effects of linoleic acid on neutrophil oxygen metabolism and phagocytosis. J Invest Dermatol 1990;95:271–274.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.