Acneiform dermatoses are follicular eruptions. The initial lesion is inflammatory, usually a papule or pustule. Comedones are later secondary lesions, a sequel to encapsulation and healing of the primary abscess. The earliest histological event is spongiosis, followed by a break in the follicular epithelium. The spilled follicular contents provokes a nonspecific lymphocytic and neutrophilic infiltrate. Acneiform eruptions are almost always drug induced. Important clues are sudden onset within days, widespread involvement, unusual locations (forearm, buttocks), occurrence beyond acne age, monomorphous lesions, sometimes signs of systemic drug toxicity with fever and malaise, clearing of inflammatory lesions after the drug is stopped, sometimes leaving secondary comedones. Other cutaneous eruptions that may superficially resemble acne vulgaris but that are not thought to be related to it etiologically are due to infection (e.g. gram-negative folliculitis) or unknown causes (e.g. acne necrotica or acne aestivalis).

1.
Bedane C, Souyri N: Les acnés induites. Ann Dermatol Vénéréol 1990;117:53–58.
2.
Hurwitz RM: Steroid acne. J Am Acad Dermatol 1989;21:1179–1181.
3.
Greenberg RD: Acne vulgaris associated with antigonadotropic (danazol) therapy. Cutis 1979;24:431–432.
4.
Sullivan M, Zeligman I: Acneform eruption due to corticotropin. Arch Dermatol 1956;73: 133–141.
5.
Bean SF: Acneiform eruption from tetracycline. Br J Dermatol 1971;85:585–586.
6.
Sherertz EF: Acneiform eruption due to ‘megadose’ vitamins B6 and B12. Cutis 1991; 48:119–120.
7.
Dupré A, Albarel N, Bonafe JL, Christol B, Lassere J: Vitamin B-12 induced acnes. Cutis 1979;24:210–211.
8.
Greenwood R, Fenwick PBC, Cunliffe WJ: Acne and anticonvulsants. Br Med J 1983;287: 1669–1670.
9.
Kanzaki T: Acneiform eruption induced by lithium carbonate. J Dermatol 1991;18: 481–483.
10.
Vexiau P, Gourmel B, Castot A, Husson C, Rybojad M, Julien R, Fiet J, Hardy N, Puissant A, Cathelineau G: Severe acne due to chronic amineptine overdose. Arch Dermatol Res 1990;282:103–107.
11.
Cohen LK, George W, Smith R: Isoniazid-induced acne and pellagra: Occurrence in slow inactivators of isoniazid. Arch Dermatol 1974; 109:377–381.
12.
Burkhart CG: Quinidine-induced acne. Arch Dermatol 1981;117:603–604.
13.
Schmoeckel C, Von Liebe V: Akneiformes Exanthem durch Azathioprin. Hautarzt 1983; 34:413–415.
14.
Bencini PL, Montagnino G, Crosti C, Sala F, DeVecchio A: Acne in a kidney transplant patient treated with cyclosporin A. Br J Dermatol 1986;114:396–397.
15.
Lowe L, Herbert AA: Cystic and comedonal acne: A side effect of etretinate therapy. Int J Dermatol 1989;28:482.
16.
Hitch JM: Acneform eruptions induced by drugs and chemicals. JAMA 1967;200: 879–880.
17.
Heydenreich G: Testosterone and anabolic steroids and acne fulminans. Arch Dermatol 1989;125:571–572.
18.
Choi EH, Bang D: Acne fulminans and 13-cis-retinoic acid. J Dermatol 1992;19:378–382.
19.
Van Scott EJ, MacCardle C: Keratinization of the duct of the sebaceous gland and growth of the hair follicle in the histogenesis of acne in human skin. J Invest Dermatol 1956;27: 405–413.
20.
Manok M: Zur Pathogenese der Bromakne. Dermatologica 1963;127:375–380.
21.
Soper LE, Vitez TS, Weinberg D: Metabolism of halogenated anesthetic agents as a possible cause of acneiform eruptions. Anesth Analg 1973;52:125–127.
22.
Harrell BL, Rudolph AH: Kelp diet: A cause of acneiform eruption. Arch Dermatol 1976;112: 560.
23.
Fulton JE, McGinley K, Leyden JJ, Marples R: Gram-negative folliculitis in acne vulgaris. Arch Dermatol 1968;98:349–353.
24.
Plewig G, Braun-Falco O: Gramnegative Follikulitis. Hautarzt 1974;25:541–546.
25.
Leyden JJ, Marples RR, Mills OH Jr, Kligman AM: Gram-negative folliculitis – A complication of antibiotic therapy in acne vulgaris. Br J Dermatol 1973;88:533–538.
26.
Neubert U: Immunabweichungen bei sogenannter Gramnegativer Follikulitis. Hautarzt 1983;34(suppl 6):277–278.
27.
Neubert U, Plewig G, Ruhfus A: Treatment of gram-negative folliculitis with isotretinoin. Arch Dermatol Res 1986;278:307–313.
28.
Plewig G, Nikolowski J, Wolff HH: Action of isotretinoin in acne, rosacea and gram-nega-tive folliculitis. J Am Acad Dermatol 1982;6: 766–785.
29.
Milde P, Goerz G, Plewig G: Acne necrotica (varioliformis). Nekrotisierende lymphozytäre Follikulitis. Hautarzt 1993;44:34–36.
30.
Maibach H: Scalp pustules due to Corynebacterium acnes. Arch Dermatol 1967;96: 453–455.
31.
Lane JE: Acne necrotica miliaris of the scalp. Arch Dermatol Syphilol 1933;28:10–12.
32.
Montgomery H: Acne necrotica miliaris of the scalp: A clinical and histological study. Arch Dermatol Syphilol 1937;36:40–44.
33.
Kossard S, Collins A, McCrossin I: Necrotizing lymphocytic folliculitis: The early lesion of acne necrotica. J Am Acad Dermatol 1987;16: 1007–1014.
34.
Hersle K, Mobacken H, Moller A: Chronic non-scarring folliculitis of the scalp. Acta Derm Venereol (Stockh) 1979;59:249–253.
35.
Stritzler C, Friedman R, Loveman AB: Acne necrotica: Relation to acne necrotica miliaris and response to penicillin and other antibiotics. Arch Dermatol Syphilol 1951;64:464–469.
36.
Hjorth N, Sjolin KE, Sylvest B, Thomsen K: Acne aestivalis – Mallorca acne. Acta Derm Venereol (Stockh) 1972;52:61–63.
37.
Nielson EB, Thorman J: Acne-like eruptions induced by PUVA treatment. Acta Derm Venereol (Stockh) 1978;58:374–375.
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