Malignant melanoma arising in a burn scar is very rare. Only 12 cases have been reported until now. We report a case of multiple malignant melanoma and squamous-cell carcinoma arising in the same burn scar. Reported cases of malignant melanoma arising in burn scars are also reviewed. Results of immunohistochemical studies and HLA typing of our patient and a review of previous cases suggest the aggressive behavior of malignant melanoma in burn scars.