Abstract
Objective: Developing a technique for quantifying the number and size of follicular casts and microcomedones. Background: There is no human testing that is validated up to now to predict comedogenesis and comedolysis following topical applications of drugs or cosmetics. Design: Evaluations are performed by digital image analysis of cyanoacrylate follicular biopsies. The effects of two topical products are compared. Results: Microcomedogenesis was disclosed after a 2-month period of application of a cosmetic product aimed at treating acne. Microcomedolysis occurred following usage of a topical preparation containing benzoyl peroxide 5% and miconazole nitrate 2%. Conclusion: Digital image analysis of skin surface biopsies is a sensitive method documenting microcomedo formation and dissolution.