Four patients with systemic scleroderma and 1 patient with localized scleroderma were treated with ciclosporin (CS) given in daily doses between 2.2 and 5.6 mg/kg body weight for 3–26 months. Under this medication clinical improvement was observed in 4 patients with partial regression of cutaneous sclerosis and inflammation, healing of fingertip ulcerations or leg ulcers and improvement of articular mobility. However, in 1 patient with rapidly advancing systemic scleroderma a short-term therapy with CS in low doses (2–3 mg/kg body weight) resulted in arterial hypertension and renal dysfunction. Therefore careful selection of patients and close-meshed controls are indicated when CS is considered as anti-inflammatory treatment in scleroderma.

Keywords:
Ciclosporin, Systemic scleroderma, Localized scleroderma
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© 1999 S. Karger AG, Basel
1990
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