The effects of therapy with danazol or stanozolol on complement component C4 and on C1 inhibitor concentrations and functions in 6 patients suffering from the common form of hereditary angioedema are described. Whereas the mean C4 concentration was found within the normal range, the therapy with attenuated androgens resulted in a subnormal mean of C1 inhibitor concentration, but an almost normal mean of functional activity.

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