Measurements of the water content of the stratum corneum were made on the flexor side of the forearm in healthy male volunteers using direct current resistance and alternating current (1.5 and 15 kHz) electric impedance measurements, capacity measurements and measurements of transepidermal water loss. In addition, infrared-spectroscopic investigations were made using a Frustrated Multiple Internal Reflection device on unstripped skin, then on the same skin area after five and ten strippings with adhesive tape. The tests showed (except for the measurements of transepidermal water loss) all of the aforementioned test methods led to relevant measurement values. While the direct current electrical resistance measurement yielded data on the water content of the most superficial layer of the stratum corneum, it was found that the capacitor measurements gave results from the deep layers of the stratum corneum. With the alternating current impedance measurement method, both superficial and deep layers of the stratum corneum were taken into account. Comparative measurements of direct current resistance and infrared absorption after occlusion treatment revealed that under certain circumstances using both methods can lead to contradictory results.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.