A patient with systemic lupus erythematosus with predominant skin involvement is described. A good correlation between disease activity manifested by skin lesions and between the titer of anti-DNA antibodies and C 3 component of complement was observed. Disease activity was accompanied by a high titer of anti-DNA antibodies and by a low level of the C3 component of complement; these parameters were reversed during remission. We conclude that these parameters are useful in the diagnosis and management of patients with systemic lupus erythematosus limited to the skin.

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