...Shereen Zakauddin; Rosemary D. Leake; Carl W. Trygstad The effect of theophylline on glomerular filtration rate was studied in nine,5- to 19-day-old pretcrrn infants (mean wcight 1,115 gJ with apnea of prematurity. Glomerular filtration rate as inulin clearance and fractional sodium reabsorption...

...Donald Hilligoss; William Jusko; Jeffrey Koup; George Giacoia Theophylline disposition was examined in 17 premature neonates (birth weight 760-1,480 g) at cessation of therapy for primary apnea. Mean ± SD of clearance(22.9 ± 3.9 ml/h/kg) and apparent volume of distribution (0.630 ± 0.150 l/kg) were...

...Joseph N. Miceli; Barbara Clay; Larry E. Fleischmann; Ashok P. Sarniak; Regine Aronox; Alan K. Done In a patient severely poisoned with theophylline, saturation kinetics were demonstrated at serum concentrations > 35 μg/ml with subsequent conversion to first order kinetics (t(1/2) = 5.4 h...

...R. M. Nelson; M. B. Resnick; W. J. Holstrum; D. V. Eitzman The methylated xanthines are known to have multiple metabolic effects. This study was performed to examine the development of premature infants treated with theophylline in the neonatal period for apnea. The theophylline-treated infants had...

...% at birth and on the 15th day of life. Ten neonates were studied during daily therapy with caffeine for prophylaxis of idiopathic apnea. The time course of plasma and urinary concentrations of caffeine and theophylline shows that caffeine is transformed to theophylline at birth, while total urinary...

...J.L. Brazier; B. Salle; B. Ribon; M. Desage; H. Renaud We studied the metabolism of theophylline in premature neonates by the use of molecules labelled with stable isotopes. 2 prematures received from birth up to 8th day of life 3 mg/kg/8 h of a mixed solution containing 46% of labelled and 54...

...Elke Jager-Roman; Peter E. Doyle; David Thomas; Judy Baird-Lambert; Mara Cvejic; Neil Buchanan The pattern of theophylline metabolites in plasma was studied in 9 preterm neonates of 28-35 weeks gestation. In infants not exposed to corticosteroids prenatally,metabolite formation was dependent...

...M. Bonati; R. Latini; G. Marra; B.M. Assael; R. Parini Theophylline (T) tissue distribution was studied in 11 premature newborns treated with T for prematurity apnea, who had died from severe pathology. To investigate the pattern of distribution of T, in particular the role of the blood-brain...

...Fernando R. Moya; Ian Gross In an attempt to resolve conflicting reports on the effectiveness of theophylline in stimulating fetal lung surfactant production in vivo, we examined the influence of theophylline on fetal rat lung phosphatidylcholine synthesis. Intraperitoneal administration...

...Neil N. Finer; Kathrine L. Peters; Linda M. Duffley; James H. Coward 19 infants admitted with a diagnosis of infantile apnea who were found to have periodic breathing were given oral theophylline to determine its effect. They were studied at a mean age of 7.1 weeks (1-16.4 week). Each infant...

... forms of P-450 in detoxifying theophylline and zoxazolamine and in enhancing the toxicity of acetaminophen. Cimetidine in vivo blocks these metabolic pathways, resulting in increased toxicity of theophylline and zoxazolamine and protection against acetaminophen toxicity. These data illustrate the double...

...Henry R. Boer; Peter Gal Theophylline has been extensively used in neonatal medicine in the management of apnea and bradycardia in premature infants [1]. Several authors have indicated that serum theophylline concentrations between 6 and 12 pg/ml are safe and effective [2, 3] and that a maintenance...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Newborn Caffeine Theophylline Drug metabolism Enzyme development 1610825 Dev. Pharmacol. Then 7: suppl. 1, pp. 18-25 (1984) Ontogeny of Human Caffeine and Theophylline...

...Lynne D. Willett; Carol A. Huseman; Robert M. Nelson; M.M. Varma Caffeine has been shown to markedly alter growth hormone (GH), thyroid stimulating hormone (TSH), and thyroid hormones in animal studies. Similar studies in the human are lacking. To determine the effect of theophylline treatment...

...Narinder Khanna; Satu M. Somani; Ann Boyer; John Miller; Carlos Chua; James A. Meneke We have previously described the relationships of serum and saliva concentrations of caffeine, theophylline and total methylxanthines in premature infants. We have now extended the previous studies in order...

...Gregory L. Kearns; Donald E. Hill; M.E. Tumbelson A pharmacokinetic study to evaluate the piglet as a model for caffeine and theophylline disposition was undertaken in 28 animals who received a 10.0-mg/kg intravenous dose of either methylxanthine, followed by multiple blood sampling over a 24-hour...