...Jie Yin; Richard P. Wennberg; Yuncheng Xia; Jia Wei Liu; Hanzhao Zhou Oral administration of Yin Zhi Huang (YZH) daily for 3 days in rabbits accelerated plasma clearance of infused unconjugated bilirubin. A similar but less dramatic effect resulted from 3 days pretreatment with phenobarbital, 70 mg...

...Jie Yin; Marion Miller; Richard P. Wennberg Daily administration of either phenobarbital (60 mg/kg) or yin zhi huang (YZH,30-60 ml/kg) for 5 days to rats similarly accelerated the clearance and conjugation of intravenously infused bilirubin. However, the two drugs had quite different effects...

...Maria Pia De Carolis; Umberto Muzii; Costantino Romagnoli; Antonio Alberto Zuppa; Enrico Zecca; Giuseppe Tortorolo The serum concentration of phenobarbital used as an anticonvulsant was monitored in 30 preterm babies. The therapeutic serum concentration was achieved with a loading dose of 20 mg/kg...

...P. Monin; J.M. Hascoet; P. Vert The effect of phenobarbital and pancuronium on cerebral blood flow (CBF) and CBF autoregulation are studied in newborn piglets after chemically induced seizures with bicuculline. Given 3 or 15 min after the onset of seizures, phenobarbital significantly reduces CBF...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Phenobarbital Phototherapy Hyperbilirubinemia Neonate 1610855 Dev. Pharmacol. Then 7: suppl. 1, pp. 190-193 (1984...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Phenobarbital Pharmacokinetics Premature newborn 1610853 Dev. Pharmacol. Then 7: suppl. 1, pp. 177-184 (1984...

...M. Bourin; A. Mouzard; M.F. Kergueris; Y. Le Normand; C. Larousse 11 8 2017 1610852 Dev. Pharmacol. Then 7; suppl. 1, pp. 171-176 (1984) Changes in Phénobarbital Concentrations in the Cerebrospinal Fluid and Blood of the Newborn M. Bourina, A. Mouzardh, M.F. Kerguerisa, Y. Le Normand3, C...

...D. Alix; F. Berthou; C. Riche; Y. Castel Phenobarbital was used as first treatment in 198 subjects with different loading doses adjusted according to age, followed by a daily maintenance dose of 5 mg/kg. A loading dose was given per os to 136 infants in four groups and intravenously to 62 subjects...

...W. Kuhnz; S. Koch; H. Helge; H. Nau A total of 35 newborns whose mothers had been treated with either primidone(PMD), phenobarbital (PB) or a combination of one of these drugs with other antiepileptic drugs were included in this study. Fetal/matemal serum concentration ratios at birth, milk/serum...

... resistant to phénobarbital,is reported in this pilot study. The clinical and electroencephalogram control of seizures was prompt and resolute. No adverse effect on cardiovascular function (heart rate, blood pressure)was observed. The terminal half-life of thiopental averaged 9 h, the total plasma clearance...

...M.P. De Carolis; C. Romagnoli; S. Frezza; E. D'Urzo; U. Muzii; A. Mezza; S. Ferrazzani; S. De Carolis The placental transfer of phénobarbital was investigated in 35 mother-infant pairs at birth. The drug was administered prenatally to the mothers for maternal epilepsy (group 1, n = 5),gestational...

...Emmanuel Scalais; Kay Beharry; Apostolos Papageorgiou; Michel Bureau; Jacob V. Aranda To determine the neonatal cerebrovascular effect of a therapeutic dose and a high dose of phénobarbital (Pb), the effect of Pb on cerebral blood flow (CBF) and total brain oxygen consumption(CMR02) was studied...

...M. Clozel; J.L. Daval; P. Monin; C. Dubruc; P.L. Morselli; P. Vert The changes in cerebral blood flow (CBF) during and after bicuculline- induced seizures were studied by the radioactive microsphere technique in 12 newborn, urethan-anesthetized piglets, 6 piglets pretreated with phenobarbital (10...

... cytochrome P-450 reductase. There are several molecular forms (isozymes) of cytochrome P-450 in liver, and it has been shown that their relative concentrations change during development and in response to phénobarbital. Because substrate specificities of the isozymes differ to some extent, changes...

...Carol S. Camfield; Edgard E. Delvin; Peter R. Camfield; Francis H. Glorieux Serum 2 5-hydroxyvitamin D (25-OHD) levels were measured in 74 children randomly treated in a double-blind fashion with either 5 mg phenobarbital/kg/day or placebo after a single febrile seizure. Phénobarbital treatment...

... manner with half-lives of 4.15 and 47.7 days. Enzymes from control (ß A1DH), pregnant (it A1DH)and phenobarbital-treated (cp A1DH) were partially purified and compared. All had molecular weights of approximately 60,000 daltons. Substrate specificities were similar except that <p A1DH had a lower Km...

...Seetha Shankaran; Eugene E. Cepeda; Nestor Ilagan; Ralph E. Kauffman The transplacental and elimination pharmacokinetics of phenobarbital administered antenatally was analyzed in both mothers and infants as part of a study evaluating the efficacy of antenatally administered phenobarbital...

... using human serum albumin and the peroxidase method. Combinations of aminophylline with phénobarbital, cefotaxime and vancomycin were studied as well as the combination of vancomycin and cefotaxime. The results show that the bilirubin-displacing effect of the drug combinations cannot be predicted from...

...Yasuhiro Suzuki; S. Cox; John Hayes; P.D. Walson Steady-state plasma phenobarbital (PB) concentrations (n = 671) were measured in 438 inpatients. There was a significant relationship between age and PB dose ratio (concentration/dose or 1/clearance) for monotherapy patients; the dose ratio declined...

...Peter Gal; Jamie Toback; N.V. Erkan; Henry R. Boer Phenobarbital dosing requirements and plasma clearance were examined for asphyxiated and nonasphyxiated neonates. The gestational age, postnatal age, duration of phenobarbital therapy and plasma phenobarbital concentrations were similar for the two...