...Anne M. Lynn; Teresa I. McRorie; John T. Slattery; Dianne Calkins; Kent E. Opheim We report the pharmacokinetics of morphine administered as intravenous boluses in newborn (<7 days) and 3- to 4-month-old macaque monkeys. Morphine was administered in a series of bolus doses until Pa(CO(2...

...Allan Weber; Ronald de Groot; Bonnie Ramsey; Judy Williams-Warren; Arnold Smith Probenecid pharmacokinetics were studied in 5 cystic fibrosis (CF) subjects and 5 control subjects at oral dosages of 5, 15, and 30 mg/kg. Serum and urine samples were collected for 8 h after administration and assayed...

... and duration of therapy. No significant differences in pharmacokinetics occurred in patients who received parenteral alimentation. While some variability and age dependence exists in thcophylline disposition in newborns, such variability is substantially less than found in older children andin adults. 19...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Theophylline Pharmacokinetics Peritoneal dialysis Toxicity management Clearance 11 11111 1602064 Dev. Pharmacol. Ther. 1: 16-25 (1980...

...Donald B. Wiest; Welton O’Neal; J. Routt Reigart; Richard C. Brundage; Paul C. Gillette; Richard L. Yost The pharmacokinetic parameters of ranitidine were studied following administration of a single intravenous dose in 9 critically ill infants. Ranitidine disposition was best described...

...). Caffeine Pharmacokinetics Preterm infants 1989 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording...

...J.B. Gouyon; A. Pechinot; C. Safran; P. Chretien; D. Sandre; A. Kazmierczak Pharmacokinetic parameters of cefotaxime (CTX) and its metabolite desacetylcefotaxime(DCTX) were assessed on the 3rd day of treatment in 10 preterm infants (28-37 weeks gestation) aged 3-8 days and receiving 25 mg/kg CTX...

...Emiko Morita; Nobuyasu Mizuno; Mayumi Nishikata; Keishiro Miyake The pharmacokinetics of β-lactam antibiotics in adult and neonatal rats were compared after their intravenous or oral administration. The distribution volumes of cefazolin,cefamandole and cefmetazole were larger for the neonatal than...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Nitrofurantoin Milk, human Pharmacokinetics Dev Pharmacol Ther...

...Laurene H. Wang; Abraham M. Rudolph; Leslie Z. Benet The disposition of acetaminophen was studied in adult nonpregnant ewes, neonatal lambs, pregnant ewes and their fetal lambs following single intravenous bolus doses. Comparisons of the pharmacokinetic parameters of acetaminophen were made between...

... pharmacokinetics following intravenous administration to the pregnant ewe and fetus. Following bolus doses of 0.5-4.0 mg/kg to ewes, cocaine appeared within 30 s in fetal circulation, with peak concentrations occurring in 4-5 min. The disappearance of cocaine in the fetal plasma paralleled that in maternal plasma...

...R.L. Collins-Nakai; D. Schiff; P.K. Ng Digoxin pharmacokinetics were studied in 13 low-birth-weight infants requiring digoxin therapy. Their weights ranged from 820 to 2,710 g (x̄ = 1,440 g) and gestational ages ranged from 26 to 38 weeks (x̄ = 30.9 weeks). The distribution and elimination...

..., instructions or products referred to in the content or advertisements. Pharmacokinetics Pharmacodynamics Dobutamine Dopamine Dose response Drug metabolism 1617379 Dev Pharmacol Ther 1990;14:115-124 Thresholds for the Physiologic Effects of Adrenergic Agents: A Methodologie Appraisal1 James F...

...Carl W. Kildoo; Liang-Mu Lin; Mariane H. Gabriel; Hugo L. Folli; Houchang D. Modanlou Multidose pharmacokinetics of vancomycin were studied in 15 infants with gestational age <36 weeks and suspected or confirmed Staphylococcus epidermidis infections. Postconceptional age (PCA) at the time...

...Daryl J. Mayers; K. Wayne Hindmarsh; Koravangattu Sankaran; Dennis K.J. Gorecki; G.F. Kasian Although the metabolism and pharmacokinetics of chloral hydrate (CH) have been studied in healthy adults, no comprehensive studies have been done in neonates and young infants. Major physiological...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Digoxin Pharmacokinetics Echocardiography Low birth weight infants Dev...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Pharmacokinetics Premature infants PDA lndomethacin Dev. Pharmacol. Ther. 1: 111-124 (1980) Pharmacokinetics...

...R. Bhat; D. Vidyasagar; E. Fisher; A. Hastreiter; J.L. Ramirez; L. Burns; M. Evans The pharmacokinetic profile of indomethacin administered either orally or intravenously in 13 preterm infants with significant patent ductus arteriosus (PDA) is reported. 9 infants received oral indomethacin and 4...

... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Isoniazid Pharmacokinetics Newborns Slow...

...Pamela O. Petersen; Thomas G. Wells; Gregory L. Kearns A dosing chart for amikacin (AMK) was developed from average pharmacokinetic parameters for infants with varying postnatal ages and birth weights ranging from<800 to >2,500 g. This chart was then evaluated in 38 infants (648-5,404 g; 25...