...Anne M. Lynn; Teresa I. McRorie; John T. Slattery; Dianne Calkins; Kent E. Opheim We report the pharmacokinetics of morphine administered as intravenous boluses in newborn (<7 days) and 3- to 4-month-old macaque monkeys. Morphine was administered in a series of bolus doses until Pa(CO(2...

...Allan Weber; Ronald de Groot; Bonnie Ramsey; Judy Williams-Warren; Arnold Smith Probenecid pharmacokinetics were studied in 5 cystic fibrosis (CF) subjects and 5 control subjects at oral dosages of 5, 15, and 30 mg/kg. Serum and urine samples were collected for 8 h after administration and assayed...

...Emiko Morita; Nobuyasu Mizuno; Mayumi Nishikata; Keishiro Miyake The pharmacokinetics of β-lactam antibiotics in adult and neonatal rats were compared after their intravenous or oral administration. The distribution volumes of cefazolin,cefamandole and cefmetazole were larger for the neonatal than...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Nitrofurantoin Milk, human Pharmacokinetics Dev Pharmacol Ther...

...Laurene H. Wang; Abraham M. Rudolph; Leslie Z. Benet The disposition of acetaminophen was studied in adult nonpregnant ewes, neonatal lambs, pregnant ewes and their fetal lambs following single intravenous bolus doses. Comparisons of the pharmacokinetic parameters of acetaminophen were made between...

... pharmacokinetics following intravenous administration to the pregnant ewe and fetus. Following bolus doses of 0.5-4.0 mg/kg to ewes, cocaine appeared within 30 s in fetal circulation, with peak concentrations occurring in 4-5 min. The disappearance of cocaine in the fetal plasma paralleled that in maternal plasma...

..., instructions or products referred to in the content or advertisements. Pharmacokinetics Pharmacodynamics Dobutamine Dopamine Dose response Drug metabolism 1617379 Dev Pharmacol Ther 1990;14:115-124 Thresholds for the Physiologic Effects of Adrenergic Agents: A Methodologie Appraisal1 James F...

...Carl W. Kildoo; Liang-Mu Lin; Mariane H. Gabriel; Hugo L. Folli; Houchang D. Modanlou Multidose pharmacokinetics of vancomycin were studied in 15 infants with gestational age <36 weeks and suspected or confirmed Staphylococcus epidermidis infections. Postconceptional age (PCA) at the time...

...Daryl J. Mayers; K. Wayne Hindmarsh; Koravangattu Sankaran; Dennis K.J. Gorecki; G.F. Kasian Although the metabolism and pharmacokinetics of chloral hydrate (CH) have been studied in healthy adults, no comprehensive studies have been done in neonates and young infants. Major physiological...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Digoxin Pharmacokinetics Echocardiography Low birth weight infants Dev. Pharmacol. Ther. l: 189-200 (1980...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Pharmacokinetics Premature infants PDA lndomethacin Dev. Pharmacol. Ther. 1: 111-124 (1980) Pharmacokinetics...

...R. Bhat; D. Vidyasagar; E. Fisher; A. Hastreiter; J.L. Ramirez; L. Burns; M. Evans The pharmacokinetic profile of indomethacin administered either orally or intravenously in 13 preterm infants with significant patent ductus arteriosus (PDA) is reported. 9 infants received oral indomethacin and 4...

... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Isoniazid Pharmacokinetics Newborns Slow...

...Pamela O. Petersen; Thomas G. Wells; Gregory L. Kearns A dosing chart for amikacin (AMK) was developed from average pharmacokinetic parameters for infants with varying postnatal ages and birth weights ranging from<800 to >2,500 g. This chart was then evaluated in 38 infants (648-5,404 g; 25...

...Linda A. Linday; David J. Greenblatt; Michelle P. Warren; Jerold S. Harmatz; Robert DeCresce; Cynthia Cicalese; Barbara W. LeDuc To evaluate the effect of puberty on antipyrine metabolism, we measured antipyrine pharmacokinetics in 17 healthy subjects aged 6-21 years. The subjects received a single...

...Ralph E. Kauffmann; Robert O. Bolliger; Suk Han Wan; Joseph Oren The metabolism and pharmacokinetics of orally administered naproxen were studied in 10 children aged 6-13 years. 3 patients received the drug for antipyresis and 7 for postoperative pain. The mean elimination rate constant was greater...

...R.L. Collins-Nakai; D. Schiff; P.K. Ng Digoxin pharmacokinetics were studied in 13 low-birth-weight infants requiring digoxin therapy. Their weights ranged from 820 to 2,710 g (x̄ = 1,440 g) and gestational ages ranged from 26 to 38 weeks (x̄ = 30.9 weeks). The distribution and elimination...

... and duration of therapy. No significant differences in pharmacokinetics occurred in patients who received parenteral alimentation. While some variability and age dependence exists in thcophylline disposition in newborns, such variability is substantially less than found in older children andin adults. 19...

... early adjunct in the managemcnt of severe theophylline intoxication. 11 11111 1602064 Dev. Pharmacol. Ther. 1: 16-25 (1980) Pharmacokinetics of Severe Theophylline Intoxication Managed by Peritoneal Dialysis Joseph N. Miceli, Barbara Clay, Larry E. Fleischmann, Ashok P. Sarnaik, Regine Aronow and Alan K...

...Donald B. Wiest; Welton O’Neal; J. Routt Reigart; Richard C. Brundage; Paul C. Gillette; Richard L. Yost The pharmacokinetic parameters of ranitidine were studied following administration of a single intravenous dose in 9 critically ill infants. Ranitidine disposition was best described...