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Keywords: Phénobarbital
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Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1991) 16 (3): 176–184.
Published Online: 19 February 2019
...Jie Yin; Marion Miller; Richard P. Wennberg Daily administration of either phenobarbital (60 mg/kg) or yin zhi huang (YZH,30-60 ml/kg) for 5 days to rats similarly accelerated the clearance and conjugation of intravenously infused bilirubin. However, the two drugs had quite different effects...
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1990) 14 (2): 84–89.
Published Online: 19 February 2019
...Maria Pia De Carolis; Umberto Muzii; Costantino Romagnoli; Antonio Alberto Zuppa; Enrico Zecca; Giuseppe Tortorolo The serum concentration of phenobarbital used as an anticonvulsant was monitored in 30 preterm babies. The therapeutic serum concentration was achieved with a loading dose of 20 mg/kg...
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1991) 16 (1): 59–64.
Published Online: 19 February 2019
...Jie Yin; Richard P. Wennberg; Yuncheng Xia; Jia Wei Liu; Hanzhao Zhou Oral administration of Yin Zhi Huang (YZH) daily for 3 days in rabbits accelerated plasma clearance of infused unconjugated bilirubin. A similar but less dramatic effect resulted from 3 days pretreatment with phenobarbital, 70 mg...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1990) 15 (1): 16–20.
Published Online: 11 August 2017
... resistant to phénobarbital,is reported in this pilot study. The clinical and electroencephalogram control of seizures was prompt and resolute. No adverse effect on cardiovascular function (heart rate, blood pressure)was observed. The terminal half-life of thiopental averaged 9 h, the total plasma clearance...
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1992) 19 (1): 19–26.
Published Online: 11 August 2017
...M.P. De Carolis; C. Romagnoli; S. Frezza; E. D'Urzo; U. Muzii; A. Mezza; S. Ferrazzani; S. De Carolis The placental transfer of phénobarbital was investigated in 35 mother-infant pairs at birth. The drug was administered prenatally to the mothers for maternal epilepsy (group 1, n = 5),gestational...
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1992) 19 (1): 10–18.
Published Online: 11 August 2017
...Emmanuel Scalais; Kay Beharry; Apostolos Papageorgiou; Michel Bureau; Jacob V. Aranda To determine the neonatal cerebrovascular effect of a therapeutic dose and a high dose of phénobarbital (Pb), the effect of Pb on cerebral blood flow (CBF) and total brain oxygen consumption(CMR02) was studied...
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1985) 8 (3): 189–199.
Published Online: 11 August 2017
...M. Clozel; J.L. Daval; P. Monin; C. Dubruc; P.L. Morselli; P. Vert The changes in cerebral blood flow (CBF) during and after bicuculline- induced seizures were studied by the radioactive microsphere technique in 12 newborn, urethan-anesthetized piglets, 6 piglets pretreated with phenobarbital (10...
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1983) 6 (2): 94–109.
Published Online: 11 August 2017
... cytochrome P-450 reductase. There are several molecular forms (isozymes) of cytochrome P-450 in liver, and it has been shown that their relative concentrations change during development and in response to phénobarbital. Because substrate specificities of the isozymes differ to some extent, changes...
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1983) 6 (3): 157–161.
Published Online: 11 August 2017
...Carol S. Camfield; Edgard E. Delvin; Peter R. Camfield; Francis H. Glorieux Serum 2 5-hydroxyvitamin D (25-OHD) levels were measured in 74 children randomly treated in a double-blind fashion with either 5 mg phenobarbital/kg/day or placebo after a single febrile seizure. Phénobarbital treatment...
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1981) 3 (1): 31–49.
Published Online: 11 August 2017
... manner with half-lives of 4.15 and 47.7 days. Enzymes from control (ß A1DH), pregnant (it A1DH)and phenobarbital-treated (cp A1DH) were partially purified and compared. All had molecular weights of approximately 60,000 daltons. Substrate specificities were similar except that <p A1DH had a lower Km...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1991) 17 (1-2): 95–99.
Published Online: 11 August 2017
... using human serum albumin and the peroxidase method. Combinations of aminophylline with phénobarbital, cefotaxime and vancomycin were studied as well as the combination of vancomycin and cefotaxime. The results show that the bilirubin-displacing effect of the drug combinations cannot be predicted from...
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1991) 17 (1-2): 79–87.
Published Online: 11 August 2017
...Yasuhiro Suzuki; S. Cox; John Hayes; P.D. Walson Steady-state plasma phenobarbital (PB) concentrations (n = 671) were measured in 438 inpatients. There was a significant relationship between age and PB dose ratio (concentration/dose or 1/clearance) for monotherapy patients; the dose ratio declined...
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1984) 7 (3): 145–152.
Published Online: 11 August 2017
...Peter Gal; Jamie Toback; N.V. Erkan; Henry R. Boer Phenobarbital dosing requirements and plasma clearance were examined for asphyxiated and nonasphyxiated neonates. The gestational age, postnatal age, duration of phenobarbital therapy and plasma phenobarbital concentrations were similar for the two...
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1985) 8 (2): 85–95.
Published Online: 11 August 2017
... by the physiochemical properties of the drug molecules and the pathophysiologic condition of the patient. It is observed that the peritoneal dialysis clearances of phénobarbital, amikacin and cefazolin in infants were 1.07-1.33,0.54-0.86 and 0.40-1.02 ml/min, respectively. The dosage determination in the dialysis...
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1985) 8 (6): 374–383.
Published Online: 11 August 2017
...Thaddeus H. Grasela Jr.; Steven M. Donn Routine clinical pharmacokinetic (PK) data collected from 59 preterm infants who received phénobarbital were analyzed to estimate population PK parameters. Birth weights ranged from 600 to 3,620 g (mean 1,520 g), and gestational ages ranged from 24 to 42...
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1993) 20 (3-4): 186–194.
Published Online: 11 August 2017
...Jie Yin; Richard P. Wennberg; Marion Miller Yin Zhi Huang (YZH) is a decoction of four plants which is widely used in Asia to treat neonatal jaundice. This study compares the ability of phénobarbital and the individual herbs comprising YZH, Artemisia, Gardenia, Rheum, and Scutellaria baicalensis...
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1991) 17 (3-4): 133–137.
Published Online: 11 August 2017
...E. Saliba; E. Autret; L. Khadiry; C. Chamboux; J. Laugier The effect of phenobarbital on cerebral blood flow velocity (CBFV) was studied in 12 clinically stable preterm neonates to evaluate possible mechanisms underlying its protective effect on intracranial hemorrhage. Phenobarbital at loading...
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1990) 15 (3-4): 215–223.
Published Online: 11 August 2017
...Sumner J. Yaffe; Lorah D. Dorn Phénobarbital, when administered prenatally to animals, produced profound and prominent effects on reproduction. Preliminary analysis of a unique cohort of adolescents who were exposed to phénobarbital in utero suggests that long-term effects may be evident...