...Koravangattu Sankaran; Kenneth Wayne Hindmarsh; Leonard Tan In an attempt to prove whether β-endorphin diurnal rhythm existed in neonates,17 infants with a mean (± SD) gestational age of 31.7 ± 4.8 weeks and a birth weight of 1,790 ± 898 g were studied at a mean postnatal age of 3.3 ± 0.5 days...

...L.D. Reimche; K. Sankaran; K.W. Hindmarsh; G.F. Kasian; D.K.J. Gorecki; L. Tan Chloral hydrate has been used clinically for over 100 years. There is significant paucity of information regarding chloral hydrate metabolism in neonates and infants. Chloral hydrate and its various metabolites were...

..., instructions or products referred to in the content or advertisements. Premature Neonates Idiopathic respiratory distress syndrome Superoxide dismutase Bronchopulmonary dysplasia 1617311 Dev. Pharmacol. Ther. 5: 151-161 (1982) Safety and Plasma Concentrations of Bovine Superoxide Dismutase...

...Laurence Collart; Terrence F. Blaschke; François Boucher; Charles G. Prober Data obtained from neonates receiving zidovudine as part of a phase I study were used to estimate the population pharmacokinetic parameters of this drug and to determine the minimum number of data points necessary...

...Daryl J. Mayers; K. Wayne Hindmarsh; Koravangattu Sankaran; Dennis K.J. Gorecki; G.F. Kasian Although the metabolism and pharmacokinetics of chloral hydrate (CH) have been studied in healthy adults, no comprehensive studies have been done in neonates and young infants. Major physiological...

...Marc LeBel; Liliane Ferron; Michel Masson; Jeanne Pichette; Charles Carrier Reports on fatal benzyl alcohol poisoning in premature neonates implied that the toxicity may be due to larger doses per kilogram than for adults. It has been postulated that the load of benzoic acid (metabolite of benzyl...

...G. Koren; D. Farine; H. Grundmann; J. Heyes; S. Soldin; J. Taylor; S.M. MacLeod We assessed the existence of endogenous digoxin-like substance(s) (EDLS) in mother-neonate pairs using a routine radioimmunoassay for digoxin. None of those studied had been treated with cardiac glycosides during...

...A.H. Thomson; S. Way; S.M. Bryson; E.M. McGovern; A.W. Kelman; B. Whiting The influence of a number of clinical characteristics on the population pharmacokinetics of gentamicin were examined using routine drug-monitoring data from a group of 113 neonates. The data were analyzed using the programme...

...Keith A. Rodvold; Chris A. Gentry; Gary S. Plank; Donna M. Kraus; Ellen Nickel; Jody R. Gross This study retrospectively characterized population-based pharmacokinetic parameters for gentamicin in neonates and young infants, and evaluated the predictive performance of these parameters in a Bayesian...

...J. P. Langhendries; O. Battisti; J.M. Bertrand; A. François; J. Darimont; S. Ibrahim; P. M. Tulkens; A. Bernard; J.P. Buchet; E. Scalais Neonates, especially preterms, are known to have low glomerular filtration rates (GFR). This may result in elevated trough concentrations during multiple...

...John A. Ziemniak; Ralph J. Wynn; Jacob V. Aranda; Barbara J. Zarowitz; Jerome J. Schentag Cimetidine pharmacokinetics and metabolism were studied in 2 full-term and 1 premature neonates. All infants demonstrated the capacity to eliminate cimetidine via both metabolic and renal routes. The half-life...

...Henry R. Boer; Peter Gal Theophylline has been extensively used in neonatal medicine in the management of apnea and bradycardia in premature infants [1]. Several authors have indicated that serum theophylline concentrations between 6 and 12 pg/ml are safe and effective [2, 3] and that a maintenance...

... in neonates. The pharmacokinetics of alfentanil were studied in 5 infants born at 26-35 weeks’ gestation and in 5 infants of greater than 36 weeks. All infants were studied in the first 3 days of life. After injection of 25 pg/kg alfentanil, there was no significant change in blood pressure or heart rate...

...Kenneth Wayne Hindmarsh; Koravangattu Sankaran; Valerie Gail Watson Plasma ß-endorphin concentrations were measured in two groups of neonates. The control group (group 1) consisted of 20 infants with a mean gestational age of 31.5 ± 0.6 weeks and a mean birth weight of 1,720 ± 135 g. Blood samples...

...Peter Gal; Jamie Toback; N.V. Erkan; Henry R. Boer Phenobarbital dosing requirements and plasma clearance were examined for asphyxiated and nonasphyxiated neonates. The gestational age, postnatal age, duration of phenobarbital therapy and plasma phenobarbital concentrations were similar for the two...

.... Neonates Renal maturation Betamethasone ß2-Microglobulin Gentamicin 1610731 Dev. Pharmacol. Then 8: 107-114 ( 1985) Effects of Prenatal Glucocorticoids on Renal Maturation in Newborn Infants D. MacKintosh, J. Baird-Lamberl, D. Drage, N. Buchanan Paediatric Pharmacology Unit, Department...

.... In order to determine whether plasma concentrations of CH or TCE reflect the sedative/hypnotic effects, a sedation/agitation scale was developed. Based on the results of the present study, the sedative/hypnotic effects of TCE cannot be ruled out completely. However, in the neonate, the parent drug CH seems...

...Elisabeth Autret; Jean-Paul Dutertre; Michel Breteau; Annie-Pierre Jomille; Yves Furet; Jean Laugier The pharmacokinetic parameters of paracetamol were studied after 15 min intravenous infusion of 15 mg/kg of propacetamol(Prodafalgan®) in 5 neonates aged less than 10 days and 7 infants aged between...

...Dyal C. Garg; Ronald N. Goldberg; Rex B. Woo-Ming; Donald J. Weidler The pharmacokinetic properties of thiopental were studied in 10 asphyxiated neonates (mean ± SE; birth weight, 3,244 ± 212 g; gestational age, 40 ± 1 weeks) as part of a randomized, controlled trial which tested the ability...

... and Medicine, Jewish Hospital and Medical Center of Brooklyn, Brooklyn, New York, USA Key Words. Neonates Drug withdrawal Hypertension Plasma renin activity Catecholamines Abstract. Blood pressure and plasma renin activity were studied in 13 infants ofdrugdependent mothers (heroin and/or methadone...