...Tiiu Hansson; Birgitta Näslund; Agneta Blanck; Anders Rane The effects of perinatal or neonatal morphine exposure on the hepatic steroid and xenobiotic metabolism in adult rats were studied. Early morphine exposure did not affect the 16α-hydroxylation or 5α-reduction of androstenedione in either...

... of the GT with morphine as substrate was measured in 25 fetal and 29 adult livers and found to be 0.23 ± 0.20 nmol/min/mg protein (fetal) and 1.85 ± 0.98 nmol/min/mg protein (adult). Thus, the adult to fetal ratio of morphine glucuronidation was 8. The isoenzyme of the GT catalyzing the conjugation...

...John J. Mickell; Sheila A. Pedigo; Steven E. Lucking; M. Abey Albert Mechanically ventilated children usually require a combination of sedation(morphine = M, diazepam = D) and paralysis (pancuronium = P) to minimize anxiety, discomfort,and the risks of self-extubation, tracheal injury...

...Martin S. Cohen; Abraham M. Rudolph; Kenneth L. Melmon We wanted to determine if naloxone antagonizes the direct effects of morphine transferred from the mother to her fetus and if this an tagonism resembles fetal narcotic withdrawal. After continuous infusions of morphine into pregnant ewes...

...Anne M. Lynn; Teresa I. McRorie; John T. Slattery; Dianne Calkins; Kent E. Opheim We report the pharmacokinetics of morphine administered as intravenous boluses in newborn (<7 days) and 3- to 4-month-old macaque monkeys. Morphine was administered in a series of bolus doses until Pa(CO(2...

...Mari S. Golub; John H. Eisele Jr.; John H. Anderson Maternal-fetal distribution of the opiate agents morphine and alfentanil was studied in 3 near-term sheep and rhesus monkeys. Blood samples were obtained from maternal and fetal arteries for radioimmunoassay after placement of catheters under halo...

...Milap C. Nahata; Angela W. Miser; James S. Miser; Richard H. Reuning Morphine plasma concentrations were determined in 19 children with cancer. A single dose of morphine, 0.09-0.15 mg/kg, was given intravenously over 3-5 min. The plasma concentrations of morphine ranged from 23 to 472 ng/ml at 10...

...Gian Maria Pacifici; Anders Rane The glucuronyl transferase activity was measured in the rat liver and intestinal microsomes during the neonatal development and pregnancy using 14C-morphine as substrate. During development the hepatic glucuronyl transferase activity increased 16-fold from day 1...

...Marja-Leena Pokela; Klaus T. Olkkola; Timo Seppälä; Maila Koivisto The pharmacokinetics of morphine was studied in 27 infants receiving a single intravenous dose of 0.1 mg/kg morphine after surgery (n = 23) or during mechanical ventilation (n = 4). The pharmacokinetics of morphine varied greatly...

...Anne M. Lynn; Teresa I. McRorie; John T. Slattery; Dianne F. Calkins; Kent E. Opheim Steady-state partitioning of morphine between blood and cerebrospinal fluid(CSF) was evaluated in pigtailed monkeys at three ages: 2-3 days, 1 month and 1 year. Protein binding of morphine to serum proteins...