...Donald B. Wiest; Welton O’Neal; J. Routt Reigart; Richard C. Brundage; Paul C. Gillette; Richard L. Yost The pharmacokinetic parameters of ranitidine were studied following administration of a single intravenous dose in 9 critically ill infants. Ranitidine disposition was best described...

... tension. Seven of the 10 infants had a significant decrease in TCPO(2) with a significant decrease in RQ from 0.98 ± 0.05 to 0.85 ± 0.06 (p < 0.01). In 3 patients with no significant change in TcPO(2) following intralipid administration, the RQ was initially significantly lower than the rest...

...B.M. Assael; G. Cavanna; W.J. Jusko; A. Marini; R. Parini; F. Sereni; A. Viganò The long-term disposition of gentamicin (up to 100-240 h) was studied in 13 premature newborns (33 weeks mean gestational age) and in 7 infants and children (1 month to 8 years). The data fitted bi- or triexponential...

...Gideon Koren To assess the difficulties in conducting pediatric research, we reviewed the 351 protocols dealing with research in infants and children in our institute between July 1982 and August 1988. Of the 16 rejected protocols (4.5%), 12 were drug studies, 3 dealt with the nature of course...

...(max)a measure of changes in cerebral blood flow. In 10 infants (4.7 ± 1.0 kg BW) V(max)5 min after anesthetic induction with halothane 1.5% at 33%, and in a comparable group of 10 infants (5.3 ± 1.2 kg BW) 5 min after anesthetic induction with an equipotential dose of isoflurane 2.5% at 28%. In 4...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Vitamin A Infants Cutaneous absorption Dev. Pharmacol. Then 7: suppt. 1, pp. 213-217 (1984) The Cutaneous Absorption of Vitamin A A Preliminary Study R. Calderaa, L...

...Marja-Leena Pokela; Klaus T. Olkkola; Timo Seppälä; Maila Koivisto The pharmacokinetics of morphine was studied in 27 infants receiving a single intravenous dose of 0.1 mg/kg morphine after surgery (n = 23) or during mechanical ventilation (n = 4). The pharmacokinetics of morphine varied greatly...

... of renally excreted drugs that are described by a one-compartment open model and the response of luminally active diuretics that exhibit a linear diuretic excretion rate-response relationship. The validity of the approach is verified in a study of furosemide disposition and response in 10 infants...

...Gérard Pons; Odile Carrier; Marie-Odile Richard; Elisabeth Rey; Philippe d’Athis; Claude Moran; Jean Badoual; Georges Olive Five neonates (4 premature) and 16 infants (6 prematurely born), 15-588 days old, received caffeine as citrate salt for apnea. Plasma samples were collected 0, 2, 4, 6 h after...

...Joseph Prandota; Georges Houin Using a one-compartment model, the urinary elimination kinetics of a single intravenous 1 mg/kg dose of furosemide (F) was studied in 13 infants, 9 days to 12 months old (mean 3.7 ± (SD) 3.48 months old), and 1, 23-month-old child, with bilateral multifocal pneumonia...

...Keith A. Rodvold; Chris A. Gentry; Gary S. Plank; Donna M. Kraus; Ellen Nickel; Jody R. Gross This study retrospectively characterized population-based pharmacokinetic parameters for gentamicin in neonates and young infants, and evaluated the predictive performance of these parameters in a Bayesian...