...-day-old animals to 0. 7 ± 0.1 ng /ml in 4 2-5 3-day-old animals, while the rate of release of active renin was un changed (11. 8 ± 5.1 ng/ min and 7 .5 ± 3.4 ng/min, respectively). Both isoproter-enol and furosemides timulated release of renin in all age animals while pro pranolol supressed renin...

...A. Viani; G.M. Pacifici The protein binding of furosemide was studied in the serum from 7 umbilical cords and 7 healthy adult subjects in presence or absence of bilirubin. In cord serum, the unbound fraction of furosemide (mean ± SD) was 2.32 ± 0.14 (control), 2.94 ± 0.26(200 μM bilirubin) (p...

... volume of 0.13 M sodium orthophosphate buffer (pH 7.4). At a total concentration of 2 μg/ml (therapeutic range), the unbound fraction of furosemide was 2.71 % (fetal albumin) and 2.51 % (adult albumin). Two classes of binding sites for furosemide were observed in fetal and adult albumin. The number...

...Joseph Prandota The pharmacokinetics and pharmacodynamics of furosemide (F) was studied in 8 steroid-responsive nephrotic syndrome (NS) children aged 2.8-6 years with normal renal function and a mean serum albumin concentration of 1.52 ± (SD) 0.47 g/100 ml. F was given as a single intravenous bolus...

...Antonella Viani; Gian Maria Pacifici The protein binding of furosemide was studied in the plasma of newborn infants and adult subjects. Plasma consisted of two pools obtained from 25 newborns and adult subjects. The concentrations of albumin were 36.8(newborn) and 48.3 g/l (adult). The unbound...

...Mark H. Mirochnick; Jeffrey J. Miceli; Paul A. Kramer; Dennis J. Chapron; John R. Raye Renal response to furosemide following initial and chronic doses was investigated in premature infants with bronchopulmonary dysplasia. Seven infants (mean birth weight = 890 ± 216 g, mean gestational age...

...Joseph Prandota; Georges Houin Using a one-compartment model, the urinary elimination kinetics of a single intravenous 1 mg/kg dose of furosemide (F) was studied in 13 infants, 9 days to 12 months old (mean 3.7 ± (SD) 3.48 months old), and 1, 23-month-old child, with bilateral multifocal pneumonia...

...G.M. Pacifici; A. Viani; G. Taddeucci-Brunelli The protein binding of furosemide was studied in the serum from 8 umbilical cords, in 51 children (aged between 2 weeks and 13.5 years) and in the plasma of 10 volunteers (aged between 28 and 42 years). The drug was added to the buffer to give a final...

...William J. Cashore; William Oh; Rolf Brodersen Sulfisoxazole and furosemide, 0.1-1.0 mM, both decreased reserve albumin concentration for bilirubin binding in pooled cord serum as estimated by rate of dialysis of 14C-monoacetyl-diamino-diphenylsulfone (MADDS) in undiluted serum at 3 7 0 C...

...Joseph Prandota The pharmacodynamics of 1 or 2 mg/kg of furosemide administered as a single dose orally or intravenously were studied in 34 hospitalized children (ranging in age from 9 days to 16.5 years) with normal renal function. These patients were divided into 3 groups: infants (furosemide 1...