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Keywords: Diazepam
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Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1980) 1 (6): 364–371.
Published Online: 19 February 2019
...Hisayo O. Morishima; Kaori Sakuma; Samuel L. Bruce; Hilda Pedersen; Inge Dyrenfurth; Salha S. Daniel; Mieczyslaw Finster The effects of diazepam on maternal and fetal responscs to stress were studied in 10 chronically instrumented pregnant ewes subjected to painful stimulation by clamping...
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1990) 14 (1): 20–28.
Published Online: 19 February 2019
...John J. Mickell; Sheila A. Pedigo; Steven E. Lucking; M. Abey Albert Mechanically ventilated children usually require a combination of sedation(morphine = M, diazepam = D) and paralysis (pancuronium = P) to minimize anxiety, discomfort,and the risks of self-extubation, tracheal injury...
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1990) 14 (3): 141–147.
Published Online: 19 February 2019
...Vasundhara Tolia; Sandra L. Fleming; Ralph E. Kauffman We performed a prospective, randomized, double-blind study of 41 children(6-18 years of age) who were undergoing esophagogastroduodenoscopy (EGD) to compare the efficacy of diazepam and midazolam with respect to quality of sedation and amnesia...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1987) 10 (5): 328–345.
Published Online: 11 August 2017
... of female rats during pregnancy or during lactation to diazepam, monosodium glutamate, caffeine, or maternal stress. The gestation period most sensitive to these prenatal insults was established, and some of the neurochemical and histological correlates of the resulting discrimination learning deficits were...
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1983) 6 (6): 409–418.
Published Online: 11 August 2017
...Hebe B. Greizerstein; Lorna K. Aldrich Four groups of 6 pregnant Long-Evans rats were intubated on days 6, 7, 9, 12, 15, and 18 of gestation with (a) 4 g/kg ethanol (E), (2) 10 mg/kg diazepam (D) plus isocaloric amounts of sucrose, (3) 10 mg/kg diazepam plus 4 g/kg ethanol (DE), and (4) gum arabic...
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1983) 6 (5): 347–355.
Published Online: 11 August 2017
...Bent Honoré; Rolf Brodersen; Alex Robertson The binding of indomethacin to albumin was investigated at 37 °C, pH 7.4. The first stoichiometric binding constant is 2.5 X 10^5 M^-1. Indomethacin utilizes both the bilirubin and diazepam binding functions equally. The effect on bilirubin binding...
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1982) 4 (3-4): 158–172.
Published Online: 11 August 2017
...M. Guerre-Millo; J.C. Challier; E. Rey; M. Nandakumaran; M.O. Richard; G. Olive The influence of plasma protein binding on the maternofetal transfer of diazepam was studied in the perfused human placental lobule. Substitution of buffered salt perfusate in both maternal and fetal circuits...
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1991) 17 (1-2): 100–108.
Published Online: 11 August 2017
... and then on SP-Sephadex C 50. The binding of diazepam (1 μM), salicylic acid (2 mM) and digitoxin(6 nM) to albumin (40 g/l) was measured by equilibrium dialysis at 37°C. The unbound fraction (mean ± SD) for fetal and adult albumin of diazepam was 1.86 ± 0.24 and 1.82 ±0.15% (NS), that of digitoxin was 3.18...
Journal Articles
Subject Area:
Pharmacology
Developmental Pharmacology and Therapeutics (1986) 9 (4): 241–248.
Published Online: 11 August 2017
... × 10^3 M^-1 measured by the peroxidase method. This displacement effect is also observed using pooled umbilical cord serum and pooled adult serum employing a dialysis rate method. Bumetanide competes to a lesser degree with diazepam binding to human serum albumin. No competition with diazepam occurs...