... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Fetal metabolism Benzo[a]pyrene Cytochrome P-450 Placental monooxygenase Catechol estrogens Original Papers 1617257 Dev. Pharmacol. Ther. 2: 1-16 (1981) Catechol...

... cytochrome P-450 content in the liver. Neonatal morphine exposure caused a significant decrease in body and testes weight in the adult male rat. We conclude that the effects of morphine are not confined to sex-differentiated pathways and are similar in both sexes. 19 2 2019 Dev Pharmacol Ther...

... on liver enzyme activities associated with xenobiotic metabolism and with bilirubin metabolism. Phenobarbital markedly increased cytochrome P-450 levels and the cytochrome-P-450-mediated formation of 4-hydroxybiphenyl whereas YZH had a slightly depressive effect on this enzyme system. Both drugs increased...

...Georg F. Kahl; Donata E. Friederici; Sanford W. Bigelow; Allan B. Okey; Daniel W. Nebert The murinc Ah complex represents a 'duster' of genes controlling the induction of numerous cytochrome P-450-mediated monooxygenase 'activities' by polycyclic aromatic compounds. These forms of cytochrome...

...David K. Manchester; Elizabeth H. Jacoby Human placental cytochrome P-450 monooxygenase activity toward 7-ethoxyresorufin increases in response to maternal cigarette smoking and is specifically inhibited in vitro by 7,8-benzoflavone. Using a mixture of ionic and nonionic detergents we have...

...J.P. Leroux; T. Cresteil; S. Marie Most data concerning the development and regulation of cytochrome P-450-dependent monooxygenases were obtained in experimental animals, especially rats, by two successive approaches: first, the assay of total liver cytochrome P-450 and of related monooxygenase...

...Markku Pasanen; Olavi Pelkonen; Antti Kauppila; Sang Shin Park; Fred K. Friedman; Harry V. Gelboin Two cytochrome P-450-dependent enzyme activities, 7-ethoxyresorufin O-deethylase (ERDE) and aryl hydrocarbon hydroxylase (AHH) were measured in liver microsomes from 7 human fetuses. Monoclonal...

...Sakina E. Eltom; Sang-Shin Park; Wayne S. Schwark The P-450-associated O-dealkylase activity towards ethoxy resorufin(EROD) and pentoxyresorufm (PROD) was measured in liver microsomes from 1-day-, 1-week-, 4-week-, 6-week-old and adult goats in order to characterize the ontogeny of cytochrome P-450...

...Julia D. George; Brian M. Sadler; Gerald M. Rosen; Elmer J. Rauckman Administration of l4C-leucine and δ-[3,5-3H]-aminolevulinic acid to immature male rats leads to the incorporation of radioactivity into microsomal protein, including the hemoprotein cytochrome P-450. Non-hepatic regional ischemic...

...M. Romano; G. Garattini; M. Salmona The development of cytochrome P-450, cytochrome C reductase, aryl hydrocarbon hydroxylase, styrene monooxygenase, and styrene epoxide hydrolase was studied in fresh rabbit liver nuclear and microsomal preparations. Enzymatic activities were determined in rabbit...

.... Isoxsuprine Niridazole Ah locus Cytochrome P-450 Inbred mouse strains Genetics of drug metabolism 1610896 Dev. Pharmacol. Ther. 6: 269-283 (1983) Screening of 16 Common Therapeutic Drugs Possible Association with the Ah Locus Yuan-Tsong Chen, Sanford W. Bigelow, Roy C. Levitt, Daniel W. Nebert...

...Steven D. Mercurio; Andrew M. Nemeth The endoplasmic reticulum of the liver cell, supplied with molecular oxygen and NADPH, can monooxygenate a variety of lipid soluble compounds including steroids and many drugs. The essential enzymatic steps are carried out by cytochrome P-450 and NADPH...

... pregnancy. Dietary protein deficiency (5 % lactic casein as the protein source) lowered the amount of cytochrome P-450 and the activities of epoxide hydrolase and UDP-glucuronosyltransferase (UDPGT) (l-borneol as the substrate) by about 45, 63,and 48%, for the first 8 weeks, respectively. Interestingly...

...Mhairi G. MacDonald; Michael J. Fasco,; Laurence S. Kaminsky The development of the rat hepatic microsomal mixed-function oxidase system was investigated by analyzing its components in fetal and young pups of postconceptional age 18-54 days. Cytochrome P-450 and cytochrome b5 concentrations...

...Julia D. George; Gerald M. Rosen; Elmer J. Rauckman Abdominal aorta ligation in neonatal rats was used as a model to evaluate drug-metabolizing activities after trauma. Short-term ischemic trauma (24 h) was found to have a significant effect on hepatic microsomal cytochrome P-450 content, NADPH...

..., to induce hepatic drug and bilirubin metabolizing enzymes in rats. Herbal decoctions (30 ml/kg/day) or phénobarbital (60 mg/kg/day) were administered for 5 days. Only phénobarbital increased cytochrome P-450 levels whereas Gardenia slightly decreased levels. Artemisia, Rheum and phénobarbital increased...