...Dennis Gurwitz; Henry Levison To assess the dose of oral fenoterol, a ß2-receptor stimulant, which provided optimal bronchodilation with minimal side effects, we studied 12 children using a doubleblind crossover comparison of three dose levels, 2.5, 5 and 7.5 mg, and a placebo. Ventilatory function...

...Vasundhara Tolia; Sandra L. Fleming; Ralph E. Kauffman We performed a prospective, randomized, double-blind study of 41 children(6-18 years of age) who were undergoing esophagogastroduodenoscopy (EGD) to compare the efficacy of diazepam and midazolam with respect to quality of sedation and amnesia...

... hyperthyroid (2.12 h^–1) was significantly increased (p <0.005) compared to when euthyroid (1.00 h^–1). The calculated kinetic information indicates that the disposition of PTU in children is similar to that reported in adults. 1607853 Dev. Pharmacol. Ther. Il: 73-81 (1988) Pharmacokinetics...

... of microsomal enzymes, competition for renal excretory mechanisms, possible enterohepatic recirculation, binding of drugs to tissues, effects of a drug on another drug’s metabolizing organ, and dose-dependent elimination, on increase or decrease of drug elimination rates in children, have been presented. Based...

...Gideon Koren; Gerald Goresky; Peter Crean; Julia Klein; Stuart M. MacLeod We assessed the pharmacokinetics of fentanyl in 19 infants and children undergoing cardiac surgery for correction of tetralogy of Fallot [8], A-V-canal [4] and transposition of the great arteries [7]. Distribution T(1/2...

... Prednisone L-Asparaginase Cyclophosphamide Methotrexate 6-mercaptopurine Pharmacology Cytosine arabinoside Children 1986 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form...

...-concentration relationships indicate that children, especially those under 11 years of age, may require maintenance PB doses more than 5 mg/kg/day to achieve the commonly recommended 'therapeutic' concentration range (10-40 mg/l). 1611053 Dev Pharmacol Ther 1991;17:79-87 Phénobarbital Doses Necessary to Achieve...

...Tsujimoto Aiko; Gozho Tsujimoto; Takashi Ishizaki; Shimpei Nakazawa; Ichihashi Yasuo In 2 children who accidentally received haloperidol (0.26 mg/kg in one and 0.10 mg/kg in another) from a prescription error, haloperidol concentrations in serum in both cases and in cerebrospinal fluid in one case...

...Laura L. Norling; David Goldring; Antonio Hernandez; Alan M. Robson; Michael Landt We have investigated the sodium-lithium countertransport system as a screening test for hypertensive disease in children and adolescents using the method of Canessa et al. [New Engl. J. Med. 302: 772-776, 1980...

...Shinya Ito; Yuuichi Kusunoki; Toshiaki Oka; Yoshiya Ito; Akimasa Okuno; Hajime Yoshioka Disposition of méthylprednisolone was characterized in 11 children receiving the high-dose therapy (26.0 mg/kg on average). After intravenous infusion, méthylprednisolone hemisuccinate was rapidly converted...

... children. Dose simulations were performed on the basis of individual data of each child in order to obtain steady-state plasma concentrations between 4 and 18 mg/1 permitting the best antipyretic effect for each child. In infants aged less than 10 days a 15 mg/kg dose of propacetamol four times a day (i.e...

... weeks) to study the behavioral,autonomic and side effects of caffeine. Mothers of the whole sample and children who were low caffeine users could distinguish between drug conditions by side effects. Caffeine increased autonomic reactivity of low users only. Behavioral and autonomic results were...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Cephalexin Pharmacokinetics Cystic fibrosis Children Adults 1610789 Dev. Pharmacol. Then 7; 221-228 (1984) Cephalexin Pharmacokinetics in Patients with Cystic Fibrosis 1 Milap C. Nahata...

...Milap C. Nahata; Angela W. Miser; James S. Miser; Richard H. Reuning Morphine plasma concentrations were determined in 19 children with cancer. A single dose of morphine, 0.09-0.15 mg/kg, was given intravenously over 3-5 min. The plasma concentrations of morphine ranged from 23 to 472 ng/ml at 10...

...Shinya Ito; Ryuuji Oka; Akira Tsuchida; Hajime Yoshioka We described the pharmacokinetics of acetylsalicylic acid and salicylic acid in 5 children with prior Kawasaki disease receiving buffered aspirin tablets or intravenous aspirin DL-lysine. Oral aspirin is characterized by its longer mean...

...Gideon Koren To assess the difficulties in conducting pediatric research, we reviewed the 351 protocols dealing with research in infants and children in our institute between July 1982 and August 1988. Of the 16 rejected protocols (4.5%), 12 were drug studies, 3 dealt with the nature of course...

...E. Rey; M. Nandakumaran; M.O. Richard; J.P. Loose; P. d’Athis; C. Saint-Maurice; G. Olive Flunitrazepam Pharmacokinetics Rectal administration Children 1984 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other...

...C. Hultquist; C. Lindberg; L. Nyberg; B. Kjellman; G. Wettrell Seven asthmatic children were given terbutaline intravenously. The intact drug was measured in plasma and urine, and its conjugates were measured in urine. The decreasing plasma concentrations of terbutaline did not attain a terminal...