...A. Viani; G.M. Pacifici The protein binding of furosemide was studied in the serum from 7 umbilical cords and 7 healthy adult subjects in presence or absence of bilirubin. In cord serum, the unbound fraction of furosemide (mean ± SD) was 2.32 ± 0.14 (control), 2.94 ± 0.26(200 μM bilirubin) (p...

...Per Ramløv Ivarsen; Rolf Brodersen Competitive binding of bilirubin and 5-butyl-1-cyclohexylbarbituric acid (bucolome)to human serum albumin was investigated by equilibrium dialysis, with and without added bilirubin (0.5 mol/mol albumin). Further observations were made by peroxidase oxidation...

...B. Irollo; B. Dang Vu; D. Nguyen Dai; J. Yonger The effect of sulfisoxazole, sodium salicylate, sodium cholate, urea and dimethyl sulfoxide on the kinetics of the bilirubin to human serum albumin at 24 °C and pH 7.40 was investigated. A marked decrease of the association constant was obtained...

...William J. Cashore; William Oh; Rolf Brodersen Sulfisoxazole and furosemide, 0.1-1.0 mM, both decreased reserve albumin concentration for bilirubin binding in pooled cord serum as estimated by rate of dialysis of 14C-monoacetyl-diamino-diphenylsulfone (MADDS) in undiluted serum at 3 7 0 C...

...Rolf Brodersen; Bent Friis-Hansen; Leo Stern Kemicterus is probably caused by precipitation of insoluble bilirubin acid in brain cells. The pigment is transferred from blood plasma to cells. The tendency for precipitation depends upon the ratio of unconjugated plasma bilirubin concentration...

...A. Robertson; R. Brodersen Drugs which compete with bilirubin for albumin binding may increase the risk of kemicterus. Fortunately, few drugs are strong competitors. However, in neonatology,many drugs are used simultaneously. We have studied the effect of drug combinations on bilirubin binding...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Heme oxygenase Metalloporphyrin Zinc deuteroporphyrin IX 2,4-bis-glycol Bilirubin Neonatal jaundice Intestinal absorption 1611057 Dev Pharmacol Ther 1991 ; 17:109-115 Absorption of Zinc...

...Charles Ahlfors; Mark L. Shwer; Keith B. Ford Impaired bilirubin-albumin binding (peroxidase method) was found in serum from a salicylate-toxic neonate. Bilirubin binding improved with serum dilution,indicating weak, competitive salicylate binding. The competitive effect of salicylate was much less...

...Alex Robertson; Warren Karp Bumetanide binding to human serum albumin was studied using ultrafiltration. The first stoichiometric binding constant for bumetanide is 6.4 × 10^4 M^-1. Bumetanide competes with bilirubin for human serum albumin binding, having a K(Displ) (displacement constant) of 6.2...

...David R. Davis; Roger A. Yeary The effectiveness of activated charcoal as an adjunct to phototherapy in reducing plasma bilirubin levels was studied in the jaundiced rat. The administration of charcoal either by feeding orgavage was effective in reducing plasma bilirubin levels in both the adult...

... to in the content or advertisements. Heme oxygenase Metalloporphyrin Zinc deuteroporphyrin IX 2,4 bis glycol Bilirubin Neonatal jaundice Enteral absorption 1611077 Dev Pharmacol Ther 1991;17:220-222 Oral Administration of Zinc Deuteroporphyrin IX 2,4 Bis Glycol Inhibits Heme Oxygenase in Neonatal Rats...