... in mature males. Early cimetidine exposure did not alter hepatic oxidative (cytochrome P-450 content or monooxygenase activity)or conjugative (UDP-glucuronosyltransferase activity towards testosterone, morphine, 1-naphthol, estrone, or sulfotransferase activity towards acetaminophen or glycolithocholate...

...Laurene H. Wang; Abraham M. Rudolph; Leslie Z. Benet The disposition of acetaminophen was studied in adult nonpregnant ewes, neonatal lambs, pregnant ewes and their fetal lambs following single intravenous bolus doses. Comparisons of the pharmacokinetic parameters of acetaminophen were made between...

... cortex. Synthesis of prostaglandin E(2)was higher in newborn than in adult rats. In vivo, indomethacin and acetaminophen blocked the response of the newborn rat to dehydration whereas in the weaning and adult rat the response was not changed by these inhibitors of the synthesis of prostaglandins. Our...

... of the M/P ratio with regard to time has been shown for acetaminophen under standardized biologic conditions in the lactating goat. This ratio is potentially confounded by such factors as route of administration, dose amount and duration of exposure to the drug. Each factor was evaluated by computer...

...Robert G. Peterson Physicians must carefully consider the appropriate use of antipyretic drugs in children. Despite the ubiquitous presence of acetaminophen and acetylsalicylic acid in the home, there are many factors to weigh prior to their use. The following is a discussion of these factors...

... forms of P-450 in detoxifying theophylline and zoxazolamine and in enhancing the toxicity of acetaminophen. Cimetidine in vivo blocks these metabolic pathways, resulting in increased toxicity of theophylline and zoxazolamine and protection against acetaminophen toxicity. These data illustrate the double...