The ability of microsomes isolated from liver of pregnant ewes and their fetuses at nearterm to catalyze the biotransformation of benzo[a]pyrene, hexobarbital, meperidine, methadone and morphine was investigated. Cytochromes P-450 and b(5), NADPH and NADH cytochrome c reductase, methadone and meperidine N-demethylase and morphine glucuronyltransferase activities were detected in microsomes from both maternal and fetal livers. Fetal hepatic microsomes however, lacked the ability to catalyze the hydroxylation of hexobarbital and benzo[a]pyrene.

Keywords:
Drug metabolism, Microsomes, Sheep, Maternal, Fetal, N-demethylation, Hydroxylation, Glucuronidation
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1986
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