Gentamicin tissue distribution and uptake were studied in chronically catheterized lambs in relation to their possible role in postnatal age- and hypoxemia-related effects on serum gentamicin concentration. Gentamicin serum concentration (S(Gent)) was proportional to dose and was paralleled by gentamicin delivery to specific organ tissues(D(Gent)) and tissue gentamicin content (T(Gent))- S(Gent) per dose was higher in older lambs (2-5 weeks of age) and in hypoxemic (pO(2) 36 ± 7 Torr) lambs. D(Gent) to liver, heart and adrenal tissues per unit dose was increased in response to hypoxemia. T(Gent) paralleled S(Gent) under these conditions. Hypoxemia- and age-related effects on S(Gent) were not explained by differences in T(Gent) in these lambs.

Keywords:
Gentamicin disposition, Tissue gentamicin concentration, Newborns, Postnatal age, Hypoxemia, Lambs
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1982
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