The in vitro serum protein binding of quinidine was determined in 26 pediatric patients. Group I consisted of 6 cord blood samples obtained at the time of delivery, group II of 8 infants aged 8-18 months, and group III of 12 children over the age of 2 years. The percentage of free quinidine in group I was 39.2 ± 10.8, group II 24.4 ±10.6 and group III 16.6 ± 6.5, demonstrating a larger proportion of unbound quinidine in the newborn group and an increase in protein binding with age (p < 0.0001). Therefore, the protein binding of quinidine is diminished in the neonate and young infant and may result in enhanced quinidine activity.

Keywords:
Quinidine, Protein binding, Developmental pharmacology
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1981
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