To determine the influence of oxygen on aortic tension in young and mature animals, we evaluated the response of neonatal and adult rabbit aortic rings to changes in oxygen tension. In 95% nitrogen/5% carbon dioxide, endotheliumderived nitric oxide was not a factor in the development or maintainence of low resting aortic ring tensions. However, the production of endothelium-derived nitric oxide increased in 21% oxygen/74% nitrogen/5% carbon dioxide and 95% oxygen/5 % carbon dioxide, and attenuated a concomitant endothelium-independent mechanism of increasing vascular tension. A protein kinase inhibitor, 0.2 mM l-(5-isoquinolinylsulfonyl)-2-methyl piperazine (H-7) inhibited oxygen-mediated constriction of neonatal vessels, but also significantly reduced the contractile response to 60 mM KCl. In conclusion,resting aortic tension is in part determined by oxygenmediated control of the production of endothelium-derived nitric oxide and one or more opposing endothelium-independent mechanisms of constriction.

Keywords:
Endothelium-derived relaxing factor, Nitric oxide, Oxygen, Protein kinase C, Vascular tension
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1992
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