...Emily G. Severance; Emese Prandovszky; Shuojia Yang; Flora Leister; Ashley Lea; Ching-Lien Wu; Ryad Tamouza; Marion Leboyer; Faith Dickerson; Robert H. Yolken Complex brain disorders like schizophrenia may have multifactorial origins related to mis-timed heritable and environmental factors...

... in schizophrenia and other major neurodevelopmental disorders. Studies in experimental animal models suggest that KP impairments in these diseases may originate already in utero since prenatal administration of KYNA’s bioprecursor, kynurenine, leads to biochemical and structural abnormalities as well as distinct...

... Schizophrenia Immunohistochemistry Original Paper Dev Neurosci 2018;40:278 287 DOI: 10.1159/000492271 Received: February 27, 2018 Accepted after revision: July 19, 2018 Published online: September 18, 2018 Biochemical and Morphological Characterization of a Neurodevelopmental Disorder-Related Mono-ADP...

... quinpirole (NQ; dopamine D 2 -like agonist) model of dopamine D 2 receptor supersensitivity, a rodent model of schizophrenia. NQ treatment in rats increases dopamine D 2 receptor sensitivity throughout the animal’s lifetime, consistent with schizophrenia. Animals were administered NQ (1 mg/kg) or saline (NS...

.... 3-Hydroxykynurenine Neurodevelopment Placenta Schizophrenia The kynurenine pathway (KP) constitutes the main catabolic route of the essential amino acid tryptophan in mammals. The pivotal metabolite of the pathway, L -kynurenine (“kynurenine”), is the direct bioprecursor of 2 neuroactive...

...Patricia Boksa; Ying Zhang; Dominique Nouel; Alice Wong; Tak Pan Wong Prenatal maternal infection and maternal iron deficiency during pregnancy are 2 early environmental insults associated with increased risk for schizophrenia in offspring. Substantial evidence suggests that abnormalities...

...Pablo Vázquez-Borsetti; Elena Peña; Catalina Rico; Mariana Noto; Nathalie Miller; Diego Cohon; Juan Manuel Acosta; Mariano Ibarra; Fabián C. Loidl Obstetrical complications of perinatal asphyxia (PA) can often induce lesions that, in the long-term, manifest as schizophrenia. A deterioration...

... neuropathological disorders (e.g. schizophrenia, autism). The present study sought to determine the effect of developmental age on the average number of PV+ neurons within the HPC and neocortex. The methods utilized herein were conducted with specific emphasis on the anatomical distribution of PV+ cells...

...Susan B. Powell; Asma Khan; Jared W. Young; Christine N. Scott; Mahalah R. Buell; Sorana Caldwell; Elisa Tsan; Loek A.W. de Jong; Dean T. Acheson; Jacinta Lucero; Mark A. Geyer; M. Margarita Behrens Cognitive impairments appear early in the progression of schizophrenia, often preceding the symptoms...

...Lorna Farrelly; Melanie Föcking; Yael Piontkewitz; Patrick Dicker; Jane English; Kieran Wynne; Mary Cannon; Gerard Cagney; David R. Cotter Background: Maternal infection is a risk factor for schizophrenia but the molecular and cellular mechanisms are not fully known. Myelin abnormalities...

..., instructions or products referred to in the content or advertisements. Dopamine Parkinson’s disease Restless legs syndrome Spinal cord Schizophrenia Zebrafish Dopamine is an important neurotransmitter in the central nervous system (CNS) of vertebrates, where it plays a role in a variety...

...Li-Jin Chew; Paolo Fusar-Poli; Thomas Schmitz Schizophrenia is a chronic and debilitating mental illness characterized by a broad range of abnormal behaviors, including delusions and hallucinations, impaired cognitive function, as well as mood disturbances and social withdrawal. Due...

... disorders, such as schizophrenia, affect the PFC, and one of the most consistent findings in schizophrenia is a decrease in volume and neuronal number in the MD. Therefore, understanding the role the MD plays in the development of the PFC is important and may help in understanding the progression...

... for schizophrenia. Previous work has shown that adult Grin1 mutant mice have overt deficits in habituation and sensorimotor gating, exaggerated reactivity to environmental stimuli, reduced social approach, and other alterations that reflect behavioral manifestations of schizophrenia. In humans, the emergence...

...Martin J. Schmidt; Karoly Mirnics Schizophrenia is a debilitating neurodevelopmental disorder affecting approximately 1% of the population and imposing a significant burden on society. One of the most replicated and well-established postmortem findings is a deficit in the expression of the gene...

... deficits in adulthood that model abnormalities in schizophrenia patients. A neurophysiological deficit in schizophrenia patients and their first-degree relatives is reduced gating of the P50 event-related potential (ERP). N40 ERP gating in rats may be a cross-species analog of P50 gating, and is disrupted...

... syndrome Schizophrenia Migration, ganglionic eminence neuron Calretinin Interneurons 6 01 2004 6 05 2004 22 10 2004 © 2004 S. Karger AG, Basel 2004 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other...

... of these forms have been diagnosed as schizophrenia. Very seldom, neurological symptoms, especially ataxia, occur without cognitive or psychiatric disturbances. Most of these cases have pyramidal and cerebellar symptoms, at diverse degrees. Seizures can also occur which in some cases can be early symptoms...