... propofol administration (20 mg/kg). P7 rats were exposed for 2, 4 or 6 h to propofol and killed 0, 4, 16 and 24 h after exposure. Relative caspase-3 and calpain activities were estimated by Western blot analysis of the proteolytic cleavage products of α-II-spectrin, protein kinase C and poly(ADP-ribose...

..., researchers have begun to investigate the mechanisms that regulate gliogenesis, glial cell differentiation and myelinogenesis. The progress made so far strongly implicates protein kinase C (PKC)- and protein kinase A (PKA)-mediated signaling in glial cell proliferation and differentiation. These pathways...

..., researchers have begun to investigate the mechanisms that regulate gliogenesis, glial cell differentiation and myelinogenesis. The progress made so far strongly implicates protein kinase C (PKC)- and protein kinase A (PKA)-mediated signaling in glial cell proliferation and differentiation. These pathways...

...Narayan R. Bhat; Peisheng Zhang; Aruna N. Bhat Myristoylated alanine-rich C-kinase substrate (MARCKS), a major substrate of activated protein kinase C (PKC), is thought to be involved in PKC-mediated signal transduction events. In the present study, we have examined the expression of MARCKS...

... markers, intracellular cyclic adenosine monophosphate (cAMP) levels, protein kinase C (PKC) signal transduction to extracellular signal-regulated kinase 1/2 (ERK-1/2) and cellular morphology were investigated in relation to RKIP levels. RKIP + cells showed accelerated neurite outgrowth, formation...

... h in P21 animals but not in P7 animals. Differential effects of HI on phosphorylation of the NMDA receptor at P7 and P21 may contribute to age-related changes in sensitivity to HI. Hypoxia-ischemia N-methyl- D -aspartate receptor Phosphorylation Protein kinase C Protein kinase A 17 08...

...Flavio R. Zolessi; Cristina Arruti Myristoylated alanine-rich kinase C substrate (MARCKS), an actin-binding protein, is involved in several signal transduction pathways. It is susceptible to be phosphorylated by protein kinases as protein kinase C and some proline-directed kinases...

..., the present study examined three developmentally regulated protein kinase C substrate mRNAs that are highly expressed in hippocampal granule cells during mossy fiber outgrowth: GAP-43, a presynaptic substrate implicated in axonal outgrowth, RC3 (neurogranin), a postsynaptic substrate implicated in calmodulin...

...Jochen Herms; Uwe Zurmöhle; Wolfgang Brysch; Karl-Hermann Schlingensiepen The expression of the genes encoding the alpha subunit of type-II calcium/ calmodulin-dependent protein kinase (CAM-KIIα) and the gamma subspecies of protein kinase C (PKCγ) was examined throughout postnatal rat brain...

... in OLGs can be inhibited by two distinct second messengers, cAMP acting through protein kinase A and diacylglycerol acting through protein kinase C, the effects of which perhaps converge at the level of a common phosphorylated enzyme or regulatory protein. Both cAMP and diacylglycerol have been implicated...