...Karunanithi Sivasangari; Koilmani Emmanuvel Rajan Introduction: This study was designed to examine whether social/environmental experiences can induce the epigenetic modification, and influence the associated physiology and behaviour. To test this, we have used social stress (prenatal stress [PNS...

...Lixia Li; Wenying Zhang; Congying Sun; Zhiqiang Chai; Kaiyue Wang; Qian Zhou; Xiaoying Wang Introduction: This study aimed to explore the impact and mechanism of Scutellariae radix (SR), dried root of Scutellaria baicalensis Georgi of Labiatae, on prenatal stress (PS)-induced anxiety-like...

... of psychopathologies and for trial of new therapeutic drugs. One way to model pathologies of the nervous system is to impair fetal neurodevelopment through stress of the pregnant future mother, or prenatal stress (PS). The use of variable frequency ultrasound (US) in rodents is a promising method of imitating...

...Wei He; Huimei Huang; Huiping Zhang; Hongli Sun Many investigations have indicated that prenatal stress (PS) causes depressive-like disturbances in offspring rats. However, the underlying pathogenic mechanisms have not yet been fully elucidated. The prefrontal cortex (PFC) has been shown to play...

...-performance liquid chromatography tandem mass spectrometry. Female, but not male, prenatally stressed (PNS) offspring displayed a depressive-like phenotype, mainly when in proestrus/diestrus, along with reduced hippocampal 5-HT levels and high 5-HT turnover rate in the hippocampus and brainstem. In contrast...

...Greer A. Bennett; Hannah K. Palliser; Julia C. Shaw; David Walker; Jonathan J. Hirst Prenatal stress has been associated with detrimental outcomes of pregnancy, including altered brain development leading to behavioural pathologies. The neurosteroid allopregnanolone has been implicated in mediating...

...Arif Muhammad; Bryan Kolb The present study investigated the effect of prenatal stress (PS) on juvenile behavior and adult amphetamine (AMPH) sensitization, as well as the effect of the interaction between experience (i.e. PS) and drug (i.e. AMPH) on cortical thickness and neuronal morphology...

... to be weakly associated with raised maternal cortisol, if at all. The placenta may be a more promising programming vector, because it controls fetal exposure to the maternal environment. Animal studies indicate that prenatal stress can affect the activity of the placental barrier enzyme 11-βHSD2, which...