...Shen Li; Jiao Zheng; Linlin Chai; Mengsi Lin; Ruocheng Zeng; Jianhong Lu; Jing Bian Oligodendrocyte progenitor cells (OPCs) may have beneficial effects in cell replacement therapy of neurodegenerative disease owing to their unique capability to differentiate into myelinogenic oligodendrocytes (OLs...

...-induced IUGR results in white matter injury as demonstrated by altered myelin structure and changes in the oligodendroglial cell/oligodendrocyte population. In addition, our study demonstrates that hyperoxia exposure independently results in white matter perturbation. To our knowledge, this is the first...

... the cell fate change from motor neurons (MNs) to oligodendrocyte precursor cells (OPCs) by regulating Shh signaling in the mouse ventral spinal cord in coordination with Sulf1. In the mouse, Sulf mRNAs colocalize with Shh mRNA and gradually expand dorsally from embryonic day (E) 10.5 to E12.5, following...

... in fetal neurons but predominantly in oligodendrocytes and white matter tracts in the adult brain. Because DHEA modulates glucocorticoids actions, the expression of the glucocorticoid receptor (GR) was also determined. In the brainstem, medulla, midbrain, and cerebellum, the predominant GR localization...

... and increased white matter fiber coherency in the cingulum. The number of oligodendrocytes throughout the lineage (Olig2-positive) was increased whereas more mature myelinating (CNPase-positive) oligodendrocytes were strongly decreased after LPS+HI. LPS+HI induced an increased and prolonged expression...

...Allison A. Vestal-Laborde; Andrew C. Eschenroeder; John W. Bigbee; Susan E. Robinson; Carmen Sato-Bigbee Oligodendrocytes express opioid receptors throughout development, but the role of the opioid system in myelination remains poorly understood. This is a significant problem as opioid use...

... that encodes for the gap junction protein connexin 47. Mice bearing a human Cx47M283T missense mutation have been generated as a transgenic mouse model of Pelizaeus-Merzbacher-like disease. Homozygous expression of the mutant connexin 47 gene in oligodendrocytes resulted in a complex and variable...

... the developmental window in different rodent strains that coincides with cerebral white matter development in human premature infants. To define strain-specific differences in rat cerebral white matter maturation, we analyzed oligodendrocyte (OL) lineage maturation between postnatal days (P)2 and P14 in three...

... role in oligodendrocyte survival and myelination. The purpose of this study was to test the hypothesis that the combination of IGF-1 plus hypothermia could reduce postischemic white matter damage compared with hypothermia alone. Unanesthetized near-term fetal sheep received 30 min of cerebral ischemia...

...Philippe Bürgisser; Jean-Marie Matthieu Rabbit central (CNS) and peripheral nervous system (PNS) myelin, as well as nonmyelinating pig oligodendrocytes in culture, were extracted at 0–4°C with the nonionic detergent Triton X-114. The solubilized proteins were paraffined into the detergent-rich...

...C. Eberhardt Maier; Robert H. Miller The origin of astrocytes and oligodendrocytes in the frog spinal cord, and the factors that regulate their differentiation are currently unknown. To determine the timing and pattern of glial cell differentiation, spinal cord sections from Xenopus at different...

...Cynthia S. Duchala; Kamlesh Asotra; Wendy B. Macklin Dissociated brain cell cultures are a useful model for investigating development and differentiation of oligodendrocytes in vitro. The current studies compare the developmental patterns of expression for oligodendrocyte lineage/myelin markers...

...Cynthia S. Duchala; Kamlesh Asotra; Wendy B. Macklin Dissociated brain cell cultures are a useful model for investigating development and differentiation of oligodendrocytes in vitro. The current studies compare the developmental patterns of expression for oligodendrocyte lineage/myelin markers...

...Narayan R. Bhat Growth factor-activated and cell adhesion-mediated signaling plays a crucial role in the development and differentiation of oligodendrocytes and astrocytes, the two macroglial cells of the CNS. Guided by the recent advances in the elucidation of intracellular signaling pathways...

.... Astrocytes Development Memory Myelin Neurosteroids Oligodendrocytes Pregnenolone Progesterone Regeneration Schwann cells 10 10 1995 27 10 1995 28 5 2010 astrocytes, it induced the formation of hypertrophic ceils which were highly immunoreactive for GFAP and which had...

...Narayan R. Bhat Growth factor-activated and cell adhesion-mediated signaling plays a crucial role in the development and differentiation of oligodendrocytes and astrocytes, the two macroglial cells of the CNS. Guided by the recent advances in the elucidation of intracellular signaling pathways...

... to in the content or advertisements. Astrocytes Development Memory Myelin Neurosteroids Oligodendrocytes Pregnenolone Progesterone Regeneration Schwann cells Developmental Neuroscience Original Paper Dev Neurosci 1996;18:6-21 Michael Schumachera Paul Robel Etienne-Emile Banlieuab * Lab. Honnones...

... in primary cultures of rat glial cells. Western blot analysis of different glial cell types (i.e., astrocytes, oligodendrocytes and microglia) revealed a relatively high level of MARCKS protein in oligodendrocytes. MARCKS protein and MARCKS mRNA levels in oligodendrocytes increased with time in culture...

...-deficient diets, and dysfunctional oligodendrocytes can influence the normal pattern for iron accumulation in the brain which sets off a cascade of events that results in loss of regulatory control of iron. Because iron is an essential cofactor in neurotransmitter synthesis and myelination altering iron...

... is expressed in abundance in oligodendrocytes within white-matter tracts whereas the L subunit in this .region is found only in endothelial cells of blood vessels. H-ferritin-positive cells occur in clearly defined patches which are scattered throughout the white-matter tracts. The cellular distribution...