...Leah Ever; Rui-jing Zhao; Veraragavan P. Eswarakumar; Nicholas Gaiano We used loss-of-function analysis to determine the role of fibroblast growth factor receptor 2 (FGFR2) in telencephalic progenitors, and also to examine interactions between FGFR and Notch signaling. While the telencephalon...

...Qi-Dong Hu; Quan-Hong Ma; Gianfranco Gennarini; Zhi-Cheng Xiao Increasing evidence has shown that the Notch signalling pathway regulates oligodendrogliogenesis. Upon binding to classical Delta/Serrate/Lag-2 ligands, Notch signalling promotes generation of oligodendrocyte precursor cells while...

...Xudong Yang; Taisuke Tomita; Mary Wines-Samuelson; Vassilios Beglopoulos; Malú G. Tansey; Raphael Kopan; Jie Shen The Notch signaling pathway plays a variety of roles in cell fate decisions during development. Previous studies have shown that reduced Notch signaling results in premature...

...Petur H. Petersen; Haiyan Tang; Kaiyong Zou; Weimin Zhong Asymmetric cell division is an attractive means to diversify cell fates during development and for stem cells to balance self-renewal and differentiation. In Drosophila, two signaling pathways, one mediated by Numb and the other by Notch...

... and lethal phenotypes in both Drosophila and mice. Lgl mutant cells display disruption of cell polarity, failure of asymmetric cell division, deregulation of Notch signaling and loss of proper cell fate determination. Lgl is a critical downstream target of the Par6/aPKC cell polarity complex; however...

... characterization of molecular mechanisms underlying brain development. Factors that govern cell fate choices of these neural stem cells have not been fully elucidated, but recent studies suggest that age at the time of culture is an important intrinsic mechanism. Stem cell mitogens and Notch-DSL signaling...

...Oren A. Levy; James J. Lah; Allan I. Levey The Notch signaling pathway has been implicated in the control of neurite extension, although the mechanisms are unknown. In this report, we studied the role of RBP-J/CBF-1 activation, the primary mediator of Notch signaling, in Notch-mediated regulation...