... and the Morris water maze (MWM) test at P60. T 2 -weighted MRI was conducted at P90. Diffusion tensor imaging (DTI) was subsequently performed in ex vivo brains, followed by immunohistochemical staining for changes in myelin basic protein (MBP) and neurofilament protein expression in the corpus callosum (CC...

... capture variance in biomarker concentrations over time and has been used with success in the social sciences. We used trajectory analysis to evaluate the ability of the serum concentrations of 3 brain-specific biomarkers – S100B, neuron-specific enolase (NSE) and myelin basic protein (MBP) – to predict...

... these cells are labile to commonly used techniques to introduce DNA, a transgenic system must be used for these studies. Myelin basic protein (MBP) and myelin proteolipid protein (PLP) are both highly abundant in CNS myelin, but are also produced in Schwann cells. Various lengths (6.5 kb to 256 bp...

... is missing a large segment of the myelin basic protein (MBP) gene, to investigate the possible role in cytoskeletal assembly of an MBP gene product or of other myelin components whose expression may be linked to that of MBP. In axon-free cultures, we find that approximately half of shiverer oligodendrocytes...

... is missing a large segment of the myelin basic protein (MBP) gene, to investigate the possible role in cytoskeletal assembly of an MBP gene product or of other myelin components whose expression may be linked to that of MBP. In axon-free cultures, we find that approximately half of shiverer oligodendrocytes...

... to assess whether they contain all the myelin-characteristic proteins, i.e., myelin basic protein, proteolipid protein, 2',3'-cyclic nucleotide 3'-phosphodiesterase and myelin-associated glycoprotein. We have used antibodies against these proteins as immunocytochemical probes in conjunction...

... to assess whether they contain all the myelin-characteristic proteins, i.e., myelin basic protein, proteolipid protein, 2',3'-cyclic nucleotide 3'-phosphodiesterase and myelin-associated glycoprotein. We have used antibodies against these proteins as immunocytochemical probes in conjunction...

... 2 and myelin basic protein (MBP) showed distinct patterns of behavior. P 2 was found mainly in the aqueous phase giving strong support to its theoretically predicted conformation. Eighty-nine percent of the MBP extracted from CNS myelin and 81% of the pure MBP partitioned into the detergent phase...

...Wendy B. Macklin; Cheryl L. Weill The time course of the appearance of myelin-specific markers was studied in the developing chick central nervous system (CNS). Chick CNS tissue was studied for the presence of both proteolipid and myelin basic protein by electroblotting and for 2',3'-cyclic...

...C. Barry; C. Pearson; E. Barbarese In order to meet the requirements for myelin biogenesis, the processes of oligodendrocytes must differentiate into specialized cellular compartments. For translation of myelin basic protein mRNA to occur in the oligodendrocyte processes or the myelin membrane...

...Jeff B. Ulmer; Peter E. Braun Myelin basic proteins (MBPs) can be detected in 5-day mouse brain, even though there is very little myelin present. In addition to the 4 MBP components (with molecular weights of 14, 17, 18.5 and 21.5 kilodaltons), that are commonly observed, other larger MBP-related...

... was removed, MBP was incorporated into the myelin sheath and the MBP deficit was nearly corrected. Dev. Neurosci. 6: 118-126 (1983/84) v 1984 S. Karger A G. Basel 0378-586684 OU62-OI IS $ 2.75 0 Myelin Basic Protein Deficit in the PNS of m id Mutant Mice Recovers during Development Helga Ginalski-Winkeimann...

... fiber arborization with antiserum against myelin basic protein, it was found in the reeler cerebellum that the fibers ran in all directions throughout the white matter. Some of the fibers surrounded Purkinje cells. The distribution of AChE-positive fibers was abnormal and some Purkinje cells surrounded...

... of total membrane samples from each region between 2 and 18 days of age. Proteolipid could be detected in rat spinal cord as early as 2 days of age, in lower brain stem and cerebellum by 4 days of age and in upper brain stem by 10 days of age. The time course of myelin basic protein accumulation...

... mutant mice (BALB/C) by the aggregation technique in order to analyze the pathogenesis of the shiverer mutation. The coat color was a mosaic of both strains. Immunohistochemically we have examined sections of cerebellar white matter of the chimera using antiserum against myelin basic protein (MBP), since...

... of iTBI. We compared the time course of neuron-specific enolase (NSE), S100B and myelin basic protein after pediatric hypoxic-ischemic brain injury, iTBI and noninflicted TBI (nTBI). The time to reach peak concentrations of all three biomarkers was shorter after nTBI. Initial and peak S100B, initial...

... Myelin basic protein Neural crest Glia Original Paper Dev Neurosci 2005;27:37 48 DOI: 10.1159/000084531 Received: July 12, 2004 Accepted: November 5, 2004 Inhibition of Glial Maturation by Bone Morphogenetic Protein 2 in a Neural Crest-Derived Cell Line Justin J. Dore Kate L. Crotty Susan J. Birren...

.... Brain creatine kinase Energy metabolism Translational control 3′ untranslated region Myelin basic protein Original Paper Dev Neurosci 2003;25:421 435 DOI: 10.1159/000075668 Received: August 11, 2003 Accepted: October 15, 2003 Expression of Creatine Kinase Isoenzyme Genes during Postnatal...

...] and postweaning (PND 21–63) iron deficiency on hindbrain 2′,3′-cyclic nucleotide 3′-phosphohydrolase (CNPase) activity (marker of oligodendrocyte metabolic activity) and myelin basic protein (MBP) concentrations. Both CNPase activity and concentrations in the cerebrum and hindbrain were significantly lower in pre...

... medium showed a decrease in the expression of myelin basic protein (MBP) and P₀, markers of mature myelin-forming SCs, together with an increase in the levels of p75NTR and glial fibrillary acidic protein, markers of immature SCs. Treatment with holoTf prevented the decrease in expression of MBP and P...