... fatty acid composition, peripheral (plasma IL-1β, IL-6, and C-reactive protein [CRP]) and central ( IL-1β and CD11b mRNA) proinflammatory markers, and myelin basic protein (MBP) mRNA expression were determined. Compared with CON rats, forebrain DHA levels were lower in DEF rats and higher in FO rats...

..., myelination and axon integrity, including neuronal potassium-chloride co-transporter (KCC2), myelin basic protein (MBP) and phosphorylated neurofilament (pNF), respectively. Further, we predicted that post-injury EPO treatment could mitigate CNS calpain-mediated degradation. Using prenatal transient systemic...

...Sowmya Sekizar; Abdelkrim Mannioui; Loris Azoyan; Catherine Colin; Jean-Léon Thomas; David Du Pasquier; Michel Mallat; Bernard Zalc We have generated a Xenopus laevis transgenic line, MBP-GFP-NTR, allowing conditional ablation of myelin-forming oligodendrocytes. In this transgenic line...

...Lorna Farrelly; Melanie Föcking; Yael Piontkewitz; Patrick Dicker; Jane English; Kieran Wynne; Mary Cannon; Gerard Cagney; David R. Cotter Background: Maternal infection is a risk factor for schizophrenia but the molecular and cellular mechanisms are not fully known. Myelin abnormalities...

... was observed as a decrease in ventricular ratio values and preservation of the corpus callosum thickness. Magnetization transfer values were significantly increased and matched to the recovery process of axonal myelination observed based on more-intense blue staining by solochrome cyanin. The histopathological...

...Allison A. Vestal-Laborde; Andrew C. Eschenroeder; John W. Bigbee; Susan E. Robinson; Carmen Sato-Bigbee Oligodendrocytes express opioid receptors throughout development, but the role of the opioid system in myelination remains poorly understood. This is a significant problem as opioid use...

... Stearic acid Myelin Blood-brain relationships Brain development Dev. Neurosci. 1: 153-158 (1978) Incorporation of Stearic Acid Into Brain Lipids in the Developing Brain: Blood-Brain Relationships during Development N. Gozlan-Devillierre, N. Baumann and J. M. Bourre Laboratoire de Neurochimie Inserm...

... cultures, are observed in these older cultures. Brain cell reaggregates observed at 2, 3, and 5 months of culture show signs of aging, i.e., a gradual decrease in the number of synapses, myelin degeneration and increased lipofuscin granules. 25 11 2011 © 1978 S. Karger AG, Basel 1978...

.... The results suggest an earlier maturation of the myelin lipid composition in spinal cord than in brain, which is consistent with an earlier development of a phylogenetically older organ. 25 11 2011 © 1979 S. Karger AG, Basel 1979 Copyright / Drug Dosage / Disclaimer Copyright: All rights...

... role in oligodendrocyte survival and myelination. The purpose of this study was to test the hypothesis that the combination of IGF-1 plus hypothermia could reduce postischemic white matter damage compared with hypothermia alone. Unanesthetized near-term fetal sheep received 30 min of cerebral ischemia...

..., differentiation, and health of myelinating cells of the mammalian nervous system. In this review, we will discuss how individual miRNAs regulate these various processes, and also how miRNA production in general is required for several stages of myelin generation and maintenance. 12 10 2010 28 12 2010...

...Philippe Bürgisser; Jean-Marie Matthieu Rabbit central (CNS) and peripheral nervous system (PNS) myelin, as well as nonmyelinating pig oligodendrocytes in culture, were extracted at 0–4°C with the nonionic detergent Triton X-114. The solubilized proteins were paraffined into the detergent-rich...

...Wendy B. Macklin; Cheryl L. Weill The time course of the appearance of myelin-specific markers was studied in the developing chick central nervous system (CNS). Chick CNS tissue was studied for the presence of both proteolipid and myelin basic protein by electroblotting and for 2',3'-cyclic...

...Susan Billings-Gagliardi; Daniel A. Kirschner; Nancy L. Nadon; Lynn M. DiBenedetto; Jeevajothie Karthigasan; Priscilla Lane; Gail B. Pearsall; Merrill K. Wolf This study describes a new sex-linked myelin mutation in the mouse, jimpy 4J ( Plp jp–4J ) , located in or very close to the proteolipid...

...Susan Billings-Gagliardi; Daniel A. Kirschner; Nancy L. Nadon; Lynn M. DiBenedetto; Jeevajothie Karthigasan; Priscilla Lane; Gail B. Pearsall; Merrill K. Wolf This study describes a new sex-linked myelin mutation in the mouse, jimpy 4J ( Plp jp–4J ) , located in or very close to the proteolipid...

... by Schwann cells, promotes the formation of new myelin sheaths after lesion of the mouse sciatic nerve. Thus, neurosteroids may also play an important role during regeneration of the nervous system. © 1996 S. Karger AG, Basel 1996 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved...

... by Schwann cells, promotes the formation of new myelin sheaths after lesion of the mouse sciatic nerve. Thus, neurosteroids may also play an important role during regeneration of the nervous system. 10 10 1995 27 10 1995 28 5 2010 © 1996 S. Karger AG, Basel 1996 Copyright / Drug...

...G. Blissman; S. Menzies; J. Beard; C. Palmer; J. Connor Myelination is an essential component of normal development in the brain. Thus, the factors which influence the onset of myelination need to be identified and monitored during development to insure adequate myelination. These factors may also...

...Pamela E. Knapp Proteolipid protein (PLP) is the most abundant protein of central nervous system (CNS) myelin. Because of its predicted topography, PLP has been assumed to function as a structural component of myelin, providing stability and maintaining the compact lamellar structure. However...

...Rebecca J. Hardy; Victor L. Friedrich, Jr. Myelin sheaths develop in the central nervous system (CNS) as elaborations of the processes of oligodendrocytes. Although many details of the spiral wrapping of oligodendrocyte processes around axons and their subsequent transformation into myelin sheaths...