..., instructions or products referred to in the content or advertisements. Air pollution Neurodevelopment Oxidative stress Mitochondria Air pollution is a serious common public health concern, increasingly associated with morbidity and mortality and resulting in an estimated 7 million premature...

...Xilma R. Ortiz-González Mitochondria, the organelles classically seen as the powerhouse of the cell, are increasingly associated with a wide variety of neurodevelopmental disorders. Although individually rare, a myriad of pediatric neurogenetic disorders have been identified in the last few years...

... brain Energy metabolism Metabolism Dendritogenesis Mitochondria Glycolysis NIH 26 01 2016 5 07 2016 27 09 2016 © 2016 S. Karger AG, Basel Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated...

.... Play behavior Mitochondria Autism Valproic acid Metabolism Respiration Interestingly, the antiseizure treatment known as the ketogenic diet (KD) is hypothesized to afford neuroprotection and alleviate mitochondrial dysfunction by maintaining metabolic homeostasis, thus improving neuronal...

... ]. As mitochondria depolarize, ATP-dependent uniporters, which sequester Ca 2+ within the endoplasmic reticulum and mitochondria fail, resulting in the activation of damaging proteases and kinases. In addition, excess intracellular Ca 2+ promotes the generation of free radicals (derived from oxygen and nitrogen...

...A. Almeida; K.J. Brooks; I. Sammut; J. Keelan; G.P. Davey; J.B. Clark; T.E. Bates The postnatal development of the complexes of the electron transport chain in mitochondria isolated from rat brain synaptosomes was investigated. Synaptosomal brain mitochondria were isolated from rats aged 10–60 days...

...T.E. Bates; A. Almeida; S.J.R. Heales; J.B Clark The postnatal development of the complexes of the electron transport chain in isolated rat brain mitochondria were investigated. Nonsynaptosomal brain mitochondria were isolated from rats aged 1–60 days, and the activities of mitochondrial complexes...

... peroxide could represent a specific inducer of the observed phenomenon and it may therefore be considered as an intracellular messenger involved in the regulation of some aspects of astroglial oxidative metabolism, particularly the defence against ROS. Astroglial cells Cu,Zn-SOD Mitochondria Mn-SOD...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Glutathione Mitochondria Neurodegeneration Neuronal/astrocytic trafficking Peroxynitrite 5 10 1995 7 12 1995 24 8 2009 Developmental Neuroscience...

...Casper S. Caspersen; Alexander Sosunov; Irina Utkina-Sosunova; Veniamin I. Ratner; Anatoly A. Starkov; Vadim S. Ten This work was undertaken to develop a method for the isolation of mitochondria from a single cerebral hemisphere in neonatal mice. Mitochondria from the normal mouse brain hemisphere...

... of Pittsburgh, Pittsburgh, Pa., USA Key Words Head injury Mitochondria Heat shock protein 60 Stress response Abstract Mitochondrial dysfunction occurs after traumatic brain in- jury (TBI) and contributes significantly to subsequent cell death. Heat shock protein 60 (hsp60) is a predominantly mi...

... Pyruvate Protein oxidation Mitochondria Rat brain Pediatric traumatic brain injury National Institutes of Health (NIH) 10.13039/100000002 Basic Science Research Dev Neurosci 2006;28:410 419 DOI: 10.1159/000094167 Received: December 13, 2005 Accepted: April 4, 2006 Gel-Based Hippocampal...

... labeling, numerous normal mitochondria and few cytoplasmic inclusions. In these cells, 3 H-ALA labeling largely occurred over normal mitochondria. The CSH-treated astroglia exhibited diminished 3 H-ALA labeling and contained numerous orange-red autofluorescent inclusions. The latter manifested internal...

... overload Oxidative stress Mitochondria Lipid peroxidation Dopamine Substantia nigra Complex I α-Synuclein Parkinson’s disease Iron: Oxidative Stress and Neurodegeneration Dev Neurosci 2002;24:143 153 DOI: 10.1159/000065700 Received: March 14, 2002 Accepted: June 6, 2002 Deferoxamine Attenuates...

... evidence for at least two forms of neurodegeneration, namely, acute necrosis in the forebrain and delayed neurodegeneration in the thalamus, which is death-receptor-mediated programmed cell death. Apoptosis Bax Caspase Cytochrome C oxidase Fas death receptor Mitochondria Dev Neurosci 2001;23:186...

... after HI. MPT in the cerebral cortex was measured as entrapment of DOG-6-P in mitochondria. Another group of rats was treated with the MPT inhibitor cyclosporin A (CsA; 10–50 mg/kg i.p.) or vehicle before and after HI, and the effect on brain injury and mitochondrial respiration was evaluated...

... to in the content or advertisements. Inborn errors of metabolism Mitochondria Oxidative phosphorylation Mitochondrial diseases Mathematical modelling Metabolic control theory Mitochondria, Oxidative Stress and Neurodegeneration Dev Neurosci 2000;22:399 403 Received: October 25, 1999 Accepted: March 6...

...Bruce S. Kristal; Paul N. Staats; Alexander I. Shestopalov Induction of the mitochondrial permeability transition (PT) has been proposed to contribute to neuronal cell death. Nearly all studies of the biochemistry of PT induction, however, have been conducted in isolated liver mitochondria...

...Adrienne M. Gorman; Sandra Ceccatelli; Sten Orrenius Apoptosis is a controlled form of cell death that participates in the demise of neuronal cells during development, neurodegenerative disorders and exposure to neurotoxic agents. In recent years, the mitochondria have emerged as being pivotal...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Brain Ischaemia Neonate Mitochondria Complexes Mitochondria, Oxidative Stress and Neurodegeneration Dev Neurosci 2000;22:359 365 Received: October 21, 1999 Accepted: December 3...