... metabolism. Methods: Mice underwent unilateral hypoxia-ischemia (HI) on postnatal day (P)10. Injured and sham mice were scanned at P10, P17, and P31. We used hyperpolarized 13 C MRS to investigate the metabolic exchange of pyruvate to lactate in real time during brain development following HI. 13 C-1-labeled...

... have a significant impact on patients’ quality of life. The purpose of this study was to investigate the effects of irradiation on metabolism and the possible molecular and cellular mechanisms behind such effects. Female Wistar rats were subjected to a single dose of 6-Gy whole-brain irradiation...

... (i.e. BdnfVI, Camk2a, Vamp1, Psd95, Cfl1, Pfn1, Pfn2, and Gda ) and mitochondrial function (i.e. Ucp2, Pink1, and Cox6a1 ). At 18DIV, DFO reduced key aspects of energy metabolism including basal respiration, maximal respiration, spare respiratory capacity, ATP production, and glycolytic rate, capacity...

.... Play behavior Mitochondria Autism Valproic acid Metabolism Respiration Interestingly, the antiseizure treatment known as the ketogenic diet (KD) is hypothesized to afford neuroprotection and alleviate mitochondrial dysfunction by maintaining metabolic homeostasis, thus improving neuronal...

... have significantly advanced our understanding of the mechanisms and underlying molecular underpinnings of the injury response and recovery process following a TBI in the developing brain. In this paper, normal and TBI-related alterations in growth, development and metabolism are comprehensively...

...Robert C. Vannucci; Susan J. Vannucci Early research in the Vannucci laboratory prior to 1981 focused largely on brain energy metabolism in the developing rat. At that time, there was no experimental model to study the effects of perinatal hypoxia-ischemia in the rodent, despite the tremendous need...

... disorders. However, the precise role of iron in the cause of many neurodegenerative diseases is unclear. To assist in understanding the potential importance of iron in CNS disease, this review summarizes the present knowledge in the areas of CNS iron metabolism, homeostasis and disregulation of iron balance...

...Ralf Dringen; Bernd Hamprecht The restoration of glutathione in astroglia-rich primary cultures derived from the brains of newborn rats was used to indicate metabolic properties of astroglial cells. At a culture age of 14–21 days these cultures contain an average total glutathione content of 32.8...

...A.-K. Bouzier; P. Voisin; R. Goodwin; P. Canioni; M. Merle 13 C and 1 H nuclear magnetic resonance spectroscopy (NMR) was used to investigate the metabolism of L -lactate and D -glucose in C6 glioma cells. The 13 C enrichment of cell metabolites was examined after a 4-h incubation in media...

...Arne Schousboe; Niels Westergaard; Ursula Sonnewald; Steffen B. Petersen; Rong Huang; Liang Peng; Leif Hertz Metabolism of glutamate and glutamine in cultured mouse cerebral cortical astrocytes has been investigated using either radioactively labelled ( 14 C) amino acids or 13 C-labelled amino...

...U. Sonnewald; N. Westergaard; B. Hassel; T.B. Müller; G. Unsgård; F. Fonnum; L. Hertz; A. Schousboe; S.B. Petersen Neocortical astrocytes were incubated with 13 C-labeled substrates to determine metabolic pathways. 13 C NMR spectroscopy was used to analyze 13 C incorporation into glutamine...