... of the presynaptic vesicular neurotransmitter transporters VGLUT1 and VGAT was also decreased in the tumor. Additionally, the fraction of parvalbumin and somatostatin nonneoplastic interneurons was reduced. In conclusion, changes in the levels of key proteins in neurotransmitter signaling suggest a loss of synapses...

... for excitatory synapse formation and engagement of CPd; and (iv) MBP and WFA, staining perineural nets (PNNs), marking CPd closure. ImageJ/Fiji and IMARIS were used for image processing and SPSS v24 for statistical analysis. Results: Although PV + interneuron numbers and IR intensity were unchanged, development...

...Kevin M. Goff; Ethan M. Goldberg GABAergic inhibitory interneurons of the cerebral cortex expressing vasoactive intestinal peptide (VIP-INs) are rapidly emerging as important regulators of network dynamics and normal circuit development. Several recent studies have also identified VIP...

... in inhibitory γ-aminobutyric acid (GABA) interneuron function, especially in the parvalbumin subtype of GABA interneuron, both developmentally and in adulthood, may contribute mechanistically to cognitive deficits and psychotic symptoms in schizophrenia. This study used a rat model to test whether prenatal...

..., and learning and memory behavior in rats. Structural maturity in multiple cortical regions is characterized by the appearance of parvalbumin-positive (PV + ) GABAergic interneurons and perineuronal nets (PNNs). Appearance of PV + interneurons and PNNs can serve as cellular markers for the beginning and end...

... encoding the 67-kDa isoform of glutamic acid decarboxylase (GAD67), the primary GABA-producing enzyme in the brain. GAD67 is expressed in various classes of interneurons, with vastly different morphological, molecular, and physiological properties. Importantly, GABA system deficits in schizophrenia...

...) at a final concentration of 1:20,000 and was detected with Super Signal Dura ECL (Pierce/Thermo-Fisher Scientific, Inc., Rockford, Ill., USA). By E12.5, the expression of A2bp1 was much more robust (fig. 3 ) and tracked closely with the known emergence of interneurons arising from the lateral...

...Jean-Pierre Baudoin; Chantal Alvarez; Patricia Gaspar; Christine Métin We have shown previously that actomyosin contractility plays an important role in controlling nuclear movements in future interneurons born in the medial ganglionic eminence (MGE) [Bellion et al.: J Neurosci 2005;25:5691–5699...

...Gabriela J. Martins; Céline Plachez; Elizabeth M. Powell Hippocampal interneurons arise in the ventral forebrain and migrate dorsally in response to cues, including hepatocyte growth factor/scatter factor which signals via its receptor MET. Examination of the hippocampus in adult mice in which MET...

... formation in the dentate gyrus is disturbed, as is the distribution of GABAergic interneurons. Although the p35–/– brain shows widespread abnormalities, the disorganization of the hippocampal dentate region is particularly intriguing since a similar pathology is often found in hippocampi of temporal lobe...

... syndrome Schizophrenia Migration, ganglionic eminence neuron Calretinin Interneurons 6 01 2004 6 05 2004 22 10 2004 © 2004 S. Karger AG, Basel 2004 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other...

...] of acetylcholinesterase (AChE) activity in hippocampus, neocortex and striatum as a function of prenatal Ch availability. We further measured the density of AChE-positive laminae (PD27 and PD90) and interneurons (PD20) in the hippocampus as a function of prenatal Ch availability. During ED11-ED17 pregnant Sprague-Dawley...

...Elvira Galarraga; S.T. Kitai; D. James Surmeier In the normal adult neostriatum, somatostatin immunoreactive interneurons constitute a few percent of the total neuronal population whereas substance P immunoreactive neurons, which project to the substantia nigra, constitute nearly half of the total...