... circle represents 1 neonate. Brain injury Cerebral blood flow Hypoxia Hypoxic-ischemic encephalopathy Neonates NIH Therapeutic hypothermia offers only partial neuroprotection for neonates with hypoxic-ischemic encephalopathy (HIE). Even with hypothermia, neurologic...

.... 2015 Chronic placental insufficiency Brain development Hypoxia Neurogenesis Cerebral cortex Gliogenesis Microvasculature Neurogenic niche Intrauterine growth restriction (IUGR) can have immediate and life-long consequences to the intellectual [ 1 ], cognitive [ 1 ] and motor...

...Hilde J.C. Bonestroo; Cora H. Nijboer; Cindy T.J. van Velthoven; Frank van Bel; Cobi J. Heijnen Neonatal encephalopathy due to perinatal hypoxia-ischemia (HI) is a severe condition, and current treatment options are limited. Expression of endogenous osteopontin (OPN), a multifunction glycoprotein...

... to a week. However, the effect of mild but persistent hypoxia is unknown. In this study we examined the hypothesis that mild pre-existing hypoxia (PaO 2 <17 mm Hg) would reduce neural injury in chronically instrumented late-gestation (0.85 gestation) fetal sheep exposed to 30 min of global cerebral...

...Teresa Gonya-Magee; Bradford T. Stokes The effects of acute environmental hypoxia on spinal cord polyneuronal activity throughout the later stages (14, 16 or 19 days) of chick incubation were studied. Bioelectrical activity was recorded in ovo from lumbosacral regions of the spinal cord...

...J.L. Gingras; W.A. Long; T. Segreti; M. Wasserstein The effect of chronic maternal hypoxia on substance-P immunoreactivity (SPI) was examined in brainstem regions of fetal (gestational day E-28), neonatal (postnatal days 3, 7, 14, 21), and adult rabbits. Time-dated pregnant rabbit does were housed...

... (hypoxia). In mature rats, PS were depressed by hypoxia in 6.8 min in the CA1 area and 9.8 min in the CA3 area. Subsequent recovery of PS after brief periods of hypoxia was correspondingly quicker and more complete in the CA3 area than in the CA1 area (respective mean recovery rate of PS in CA3 and CA1...

.... These studies suggest that glycolysis in astrocyte cultures is regulated by factors other than energy demand, and that the capacity of glycolysis to support astrocyte metabolism during hypoxia is markedly pH dependent. © 1996 S. Karger AG, Basel 1996 Copyright / Drug Dosage / Disclaimer Copyright: All...

..., astrocytes and cocultures thereof during normoxia and hypoxia. Lactate dehydrogenase leakage was used to monitor the cytoprotective effects of IGF-I and insulin. Thus, during normoxia both peptides decreased LDH leakage from neurons. During hypoxia, however, this protection was only observed when insulin...

...J. Zhou; L.-M. Kow; S.J. Vannucci; D.W. Pfaff; E.M. Martin Whole-cell patch clamp recordings of the electrical activity of large medullary reticular formation neurons, in nucleus gigantocellularis, were performed under control conditions and under conditions of hypoxia or anoxia. Neurons were...

...Thomas V. Dunwiddie The effects of hypoxia were studied in hippocampal slices prepared from animals of 10–120 days of age. Excitatory synaptic responses could be evoked at all ages, while inhibitory responses began to appear 14–17 days postpartum; both types of responses became maximal...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Hypoxia Ischemia Neuronogenesis Striatum Stroke Stem cells Dev Neurosci 2007;29:331 340 DOI: 10.1159/000105474...

...Ruiqiong Ran; Huichun Xu; Aigang Lu; Myriam Bernaudin; Frank R. Sharp Exposure to moderate hypoxia alone does not cause neuronal death as long as blood pressure and cerebral blood flow are maintained in mammals. In neonatal and adult mammals including rats and mice, carotid occlusion in combination...

... with neonatal hypoxic-ischemic insult. Infectious effect was produced by administrating lipopolysaccharide (LPS) intraperitoneally to pregnant rats starting on embryonic day 17. Hypoxia-ischemia (H/I) was induced in the pups at postnatal day 1 (P1) by ligature of the right common carotid artery followed...

... through microdialysis in the cortex, striatum, and periventricular white matter before, during and after severe hypoxia in newborn pigs. NPBI was analyzed by a new spectrophotometric method in which ferrous iron is chelated by bathophenanthroline. NPBI was present in all brain areas under baseline...

...Robert C. Vannucci; Susan J. Vannucci Early research in the Vannucci laboratory prior to 1981 focused largely on brain energy metabolism in the developing rat. At that time, there was no experimental model to study the effects of perinatal hypoxia-ischemia in the rodent, despite the tremendous need...

...David Edwards Preterm birth is strongly associated with neurodevelopmental impairment, but the causes of cerebral injury are not completely understood. It is often assumed that damage is due to cerebral hypoxia-ischemia secondary to the extreme stresses induced by prolonged intensive care. However...

...Nadejda Andreeva; Julia Heldt; Norbert Leclere; Johann Gross The effect of hypoxia on immature and mature mesencephalic neurons was studied in in vitro rat cerebral cell cultures on different days. In immature cultures (6–8 days in vitro), exposure to 24 h of hypoxia (10–20 mm Hg pO 2...

...), and serial two-dimensional time-resolved images of [ 18 F]FDG uptake by the slices were obtained. The Gjedde-Patlak graphical method was applied to the image data, and the duration limit of hypoxia loading that allowed recovery of the fractional rate constant (k3*) of [ 18 F]FDG (proportional to the cerebral...

...), a more potent free radical that can cause severe damage. The rapid conversion of H 2 O 2 to OH in the setting of free iron sets up the immature nervous system for increased cytotoxicity. Understanding the molecular mechanisms of oxidative stress will lead to better therapies for neonatal hypoxia-ischemia...