... the complex pathophysiology of hypoxia-ischemia (HI) has led to the discovery of several important targets for neuroprotection. Early interventions should focus on the preservation of energy metabolism, the reduction of glutamate excitotoxicity and oxidative stress, the maintenance of calcium homeostasis...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Behavioral tests Dedifferentiated fat cells Brain injury Conditioned medium Rice-Vannucci model Excitotoxicity...

... Ethyl pyruvate Octreotide Somatostatin Excitotoxicity Hypoxia-ischemia Stroke Cerebral palsy Topiramate Interactions . In analysis, the potential for there to be subsets of responders and nonresponders is rarely taken into account in preclinical studies. Despite the relative genetic...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. GABA Developing brain Perinatal pig brain Excitotoxicity Seizure...

... damage Excitotoxicity Apoptosis Myelin Dev Neurosci 2007;29:302 310 DOI: 10.1159/000105471 Received: January 6, 2007 Accepted after revision: March 28, 2007 Delayed IGF-1 Administration Rescues Oligodendrocyte Progenitors from Glutamate-Induced Cell Death and Hypoxic-Ischemic Brain Damage Teresa L...

... more vulnerable to traumatic injury. This review will focus on four main areas of secondary injury after pediatric TBI, including excitotoxicity, oxidative stress, alterations in energy metabolism and cell death pathways. Specifically, we will describe what is known about developmental differences...

... mechanisms of the SVZ response to neonatal brain injury, we used a model that focuses on a unique mechanism of vulnerability of the immature CNS, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor-mediated excitotoxicity. We previously demonstrated that intracerebroventricular injection...

...Barbara T. Felt; Timothy Schallert; Jie Shao; Yiqing Liu; Xiaoling Li; John D.E. Barks We sought to determine whether neonatal rats that sustain unilateral cerebral hypoxic-ischemic or excitotoxic insults (1) manifest contralateral sensorimotor deficits during development or in adulthood and (2...

...Paul S. Hodgkins; Robert Schwarcz Excitotoxic neuronal loss can be precipitated by defects in cerebral energy metabolism. Antagonists of excitatory amino acid receptors, such as the endogenous metabolite kynurenic acid, can effectively block excitotoxic lesions. Using brain tissue slices...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Amphetamine D1 receptor D2 receptor Excitotoxicity Kynurenines...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Excitotoxicity Dizocilpine binding Infrared differential interference contrast videomicroscopy Neostriatum N-Methyl...

... that under pathologic conditions, TNFα may impair embryonic development of the brain by exacerbating excitotoxicity. 22 12 1994 Excitotoxicity Glutamine synthetase Glutamate uptake Neuronal development Tumor necrosis factor-alpha © 1994 S. Karger AG, Basel 1994 Copyright / Drug...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Excitotoxicity GluR2 Glutamate receptors Han-Wistar rats Neurodegeneration Purkinje cells Original Paper Dev...