... the complex pathophysiology of hypoxia-ischemia (HI) has led to the discovery of several important targets for neuroprotection. Early interventions should focus on the preservation of energy metabolism, the reduction of glutamate excitotoxicity and oxidative stress, the maintenance of calcium homeostasis...

... (i.e. BdnfVI, Camk2a, Vamp1, Psd95, Cfl1, Pfn1, Pfn2, and Gda ) and mitochondrial function (i.e. Ucp2, Pink1, and Cox6a1 ). At 18DIV, DFO reduced key aspects of energy metabolism including basal respiration, maximal respiration, spare respiratory capacity, ATP production, and glycolytic rate, capacity...

... expression were involved in energy metabolism (phosphoglycerate mutase 1, α-enolase isoform 1, adenylate kinase 1, and triose phosphate isomerase) and antioxidant enzymes (superoxide dismutase 1, glutathione S-transferase ω type 1, peroxiredoxin 5, DJ-1, and glial maturation factor β). Using Western blot...

.... Astrocytes Energy metabolism Glioma Lactic acid Neurons Transport Original Paper Dev Neurosci 1995;17:63-69 Ralf Dringen Hajo Peters Heinrich Wiesinger Bernd Hamprecht Physiologisch-chemisches Institut der Universität Tübingen, Deutschland Lactate Transport in Cultured Glial Cells Key Words...

.... Northwick Park Hospital, Harrow, UK Postnatal Development of the Complexes of the Electron Transport Chain in Synaptic Mitochondria from Rat Brain Key Words Brain Complex I Complex II-II1 Complex IV Complex V Development Energy metabolism Mitochondria Synaptosomes Abstract The postnatal development...

... Development Energy metabolism Mitochondria Original Paper Dev Neurosci 1994:16:321-327 T. E. Bates'1 A. AIme¡dab S.J.R. Healesa J.B. Clark " Department of Neurochemistry. Institute of Neurology, University of London, UK: b Departamento de Bioquímica y Biología Molecular, Edificio Departamental...

... compartments of energy metabolism (or tricarboxylic acid cycle activity) in isolated synaptic terminals. 19 04 1994 5 08 1994 28 5 2010 © 1994 S. Karger AG, Basel 1994 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated...

..., instructions or products referred to in the content or advertisements. Astrocytes Compartmentation Energy metabolism Glutamate Glutamine Pyruvate Developmental Neuroscience Mary C. McKenna3 Tyson Tildón b Joseph H. Stevenson ' Xh Huang3 Department of Pediatrics and Biological Chemistry...

... bodies during suckling, postnatal increases in LCMRglcs represent a signal of the acquisition of new functions and neurological competence. β-Hydroxybutyrate Energy metabolism Glucose Postnatal development 25 09 1995 16 02 1996 24 8 2009 © 1996 S. Karger AG, Basel 1996...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Astrocytes Energy metabolism Fructose Glycogen Sorbitol Developmental...

... for defining the creatine transporter's cellular expression pattern, function in ATP homeostasis and association with disorders of cellular energy metabolism. 6 10 1995 29 02 1996 24 8 2009 © 1996 S. Karger AG, Basel 1996 Copyright / Drug Dosage / Disclaimer Copyright: All rights...

...Courtney L. Robertson; Lucian Soane; Zachary T. Siegel; Gary Fiskum Mitochondria play a central role in cerebral energy metabolism, intracellular calcium homeostasis and reactive oxygen species generation and detoxification. Following traumatic brain injury (TBI), the degree of mitochondrial injury...

.... Brain creatine kinase Energy metabolism Translational control 3′ untranslated region Myelin basic protein Original Paper Dev Neurosci 2003;25:421 435 DOI: 10.1159/000075668 Received: August 11, 2003 Accepted: October 15, 2003 Expression of Creatine Kinase Isoenzyme Genes during Postnatal...

...G.J. Kemp This review summarises the ways in which magnetic resonance spectroscopy (MRS) and related methods can be used as windows on brain energy metabolism in vivo. 31 P-MRS can measure acute changes in non-oxidative ATP synthesis in transient states, and at steady state reflects the balance...

..., instructions or products referred to in the content or advertisements. N -acetyl aspartate Mitochondria Energy metabolism MRS/MRI Neurodegradation Neuronal loss 30 10 1998 Karger Lecture Dev Neurosci 1998;20:271 276 Received: November 3, 1997 Accepted: February 4, 1998 J.B. Clark...

...G.D. Zeevalk; L.P. Bernard; C. Sinha; J. Ehrhart; W.J. Nicklas Glutamate receptor involvement and oxidative stress have both been implicated in damage to neurons due to impairment of energy metabolism. Using two different neuronal in vitro model systems, an ex vivo chick retinal preparation...

...Paul S. Hodgkins; Robert Schwarcz Excitotoxic neuronal loss can be precipitated by defects in cerebral energy metabolism. Antagonists of excitatory amino acid receptors, such as the endogenous metabolite kynurenic acid, can effectively block excitotoxic lesions. Using brain tissue slices...

... of lactate by synaptic terminals also has differences from the systems described for neurons. 30 10 1998 Lactate Pyruvate Monocarboxylic acid MCT transport Synaptic terminals Neurons Metabolic trafficking Energy metabolism 1998 Copyright / Drug Dosage / Disclaimer Copyright: All...

... death, appears mediated by the reduced level of ATP induced by the toxin. We demonstrated that 3-NPA can also impair energy metabolism in astrocytes. Exposure of astroglial cells in culture to 3-NPA leads to inhibition of the release of 3 H 2 O from [9,10(n)-3H]palmitic acid. Addition of 2 mM 3-NPA...

... to be defined manner; either by acting directly with enzymes in the metabolic pathway or via an interim (second messenger) factor. 18 8 1994 Astrocytes Energy metabolism Metabolic regulation Serum proteins Synaptosome Dev Ncurosci 1993;15:226-232 J. Tyson Tildon a ' b Mary C. McKennaa Joseph...