... dopaminergic anomalies, a coherent dopaminergic model of ASD was lacking until recently. In 2017, we provided a theoretical framework for a “dopamine hypothesis of ASD” which proposed that autistic behavior arises from a dysfunctional midbrain dopaminergic system. Namely, we hypothesized that malfunction of 2...

... quinpirole (NQ; dopamine D 2 -like agonist) model of dopamine D 2 receptor supersensitivity, a rodent model of schizophrenia. NQ treatment in rats increases dopamine D 2 receptor sensitivity throughout the animal’s lifetime, consistent with schizophrenia. Animals were administered NQ (1 mg/kg) or saline (NS...

...Denis Pavăl Autism spectrum disorder (ASD) comprises a group of neurodevelopmental disorders characterized by social deficits and stereotyped behaviors. While several theories have emerged, the pathogenesis of ASD remains unknown. Although studies report dopamine signaling abnormalities in autistic...

...-released neuropeptides on retinal neurons has been previously described. In white perch, for example, GnRH depolarizes the membrane potential of horizontal cells via dopamine and alters the receptive field of the horizontal cell [ 17 ]. In goldfish, GnRH increases the firing frequency of RGCs [ 18,19...

...María Eugenia Cornide-Petronio; Antón Barreiro-Iglesias Dopamine plays a number of important roles in the nervous system and the dopaminergic system is affected in several brain disorders. It is therefore of great interest to study the axonal guidance systems that specifically participate...

... symptoms, including cognitive impairment and anhedonia. Finally, our laboratory has reported across a series of studies that neonatal treatment with the dopamine D 2 /D 3 receptor agonist quinpirole results in long-term increases in dopamine-like receptor sensitivity, consistent with data reporting...

...-related enzymes in individual hypothalamic nuclei derived from MSG-treated rats revealed normal levels of norepinephrine, serotonin and glutamic acid decarboxylase, but reduced levels of choline acetyltransferase and dopamine in the arcuate nucleus and median eminence. Histochemical methods...

...William E. Wilson; A.K. Agrawal Brain regional levels of three neurotransmitter amines – serotonin (5-HT), norepinephrine (NE), dopamine (DA) – were measured in young rats prior to weaning to determine the extent to which modifications in levels of amines might reflect alterations in the sex...

... uptake of norepinephrine and dopamine were significantly lower in the forebrains of methadone-treated pups than in those of saline or pair-fed control offspring. On day 40, regional norepinephrine levels and uptake were similar in the brains of all three groups. However, the striata of methadone pups...

... such as attention-deficit hyperactivity disorder. Pharmacological MRI (phMRI) was used to determine the response to dopamine transporter (DAT) blockers cocaine and methylphenidate (MPH), the dopamine releaser D -amphetamine (AMPH), the selective D1 agonist dihydrexidine, and the D2/D3 agonist quinpirole in young...

... Dopamine Luteinizing hormone Follicle stimulating hormone Male rat Medial basal hypothalamus Preoptic area Dev. Neurosci. 2: 233-237 (1979) A Procedure for Purifying Neuron-Like Cells in Cultures from Central Nervous Tissue with a Defined Medium1 S'. D. Skaper, R. Adler and S. Varon Department...

... are the main focuses of this overview. Intracerebral grafting Dopamine Acetylcholine Ventral mesencephalon Septal-diagonal band Neuronal cell suspensions Neural transplantation 8 03 1984 12 04 1984 29 6 2009 © 1983 S. Karger AG, Basel 1983 Copyright / Drug Dosage...

...Aliya L. Frederick; Gregg D. Stanwood Defects in the development of the brain have a profound impact on mature brain functions and underlying psychopathology. Classical neurotransmitters and neuromodulators, such as dopamine, serotonin, norepinephrine, acetylcholine, glutamate and GABA, have...

... that the brain rapidly converts the administered L- dopa to dopamine during the first week of life and there appears to be a strong dependent relationship between the pattern of motor coordination and the amount of available dopamine in the developing brain. 18 12 2007 Dev. Neurosci. 4: 389-400 (1981...

...C.P. Phelps; L. Korányi; V. Tamásy Neonatal brain (whole brain minus cerebral hemispheres) dopamine (DA) and norepinephrine (NE) concentrations (pg/µg protein) were studied 30 min after an injection of L -DOPA methyl ester (50 mg/kg); haloperidol (1 mg/kg); D -amphetamine sulfate (0.5 mg/ kg...

...Annie Daszuta; Marie-Claude Barrit; Maxime Faudon Endogenous levels of tryptophan (TRP), serotonin (5-HT), 5-hydroxyindol acetic acid (5-HIAA), noradrenaline (NA) and dopamine (DA), were measured in the brainstem and anterior regions of C57BL and BALBc mice whose ages ranged from 1 day postnatal...

...Kiyomi Y. Araki; Satoshi Fujimura; Marcy E. MacDonald; Pradeep G. Bhide Dopamine and its receptors appear in the developing brain early in the embryonic period and dopamine receptor activation influences proliferation and differentiation of neuroepithelial precursor cells. Since dopamine D 1 and D...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Spinal cord morphogenesis Xenopus Dopamine Primary neurons Cell fate Original Paper Dev Neurosci 2005;27:306 312 DOI: 10.1159/000086710 Received: October 15, 2004...

...Margherita Popolo; Deirdre M. McCarthy; Pradeep G. Bhide Dopamine and its receptor binding sites appear in the brain early in the embryonic period raising the possibility that dopamine may influence brain development. We show that one component of dopamine’s role in brain development is its ability...

... displayed robust responses to kainate and N-methyl- D -aspartate, and these responses were modulated by dopamine. © 2003 S. Karger AG, Basel 2004 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced...