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Keywords: Cell fate determinationClose
Journal: Developmental Neuroscience
Dev Neurosci (2006) 28 (1-2): 13–24.
Published Online: 03 March 2006
... and lethal phenotypes in both Drosophila and mice. Lgl mutant cells display disruption of cell polarity, failure of asymmetric cell division, deregulation of Notch signaling and loss of proper cell fate determination. Lgl is a critical downstream target of the Par6/aPKC cell polarity complex; however...