...Jeremy R. Herrmann; Patrick M. Kochanek; Vincent A. Vagni; Keri A. Janesko-Feldman; Jason P. Stezoski; Travis C. Jackson Introduction: Neuroinflammation plays a critical role in tissue injury and repair after neonatal hypoxic-ischemic (HI) brain injury and varies by sex. Growth differentiation...

..., newborns are not diagnosed until around the time of birth, yet this diagnosis lacks further indication of the risk of brain injury or adverse neurodevelopmental outcomes. Blood biomarkers may be a promising tool. Defining blood biomarkers indicating an infant’s risk of brain injury would provide...

... Progesterone Neuroprotection Hypoxia-ischemia Hypoxic-ischemic encephalopathy Neonatal brain injury Perinatal brain injury Brain injury Despite significant advancement in the field of neonatology, hypoxic-ischaemic encephalopathy (HIE) remains one of the major contributors to early neonatal...

... alone. The pathways leading to NEC-associated neurological impairments remain unclear, limiting the development of preventative and protective strategies. This review aims to summarize the existing clinical and experimental studies related to NEC-associated brain injury. We describe the current...

...; Pelin Cengiz The variability of severity in hypoxia-ischemia (HI)-induced brain injury among research subjects is a major challenge in developmental brain injury research. Our laboratory developed a novel injury scoring tool based on our gross pathological observations during hippocampal extraction...

... identified for neonatal clinical medicine. We tested whether the hemoglobin volume phase (HVP), hemoglobin volume (HVx), and pressure passivity index (PPI) identify changes in autoregulation that are associated with brain injury on MRI or death. The HVP measures the phase difference between a NIRS metric...

..., instructions or products referred to in the content or advertisements. Periventricular white matter necrosis Brain injury Cerebral palsy Hypoxic-ischemic encephalopathy Asphyxia Neuroprotection Preterm birth (before 37 weeks gestation) remains the leading cause of childhood death...

... on microglia in vitro under normal as well as infectious and sterile inflammatory conditions, and the effect of galectin-3 on neonatal brain injury following an infectious challenge in vivo. Conditions mimicking infectious or sterile inflammation were evaluated in primary microglia cell cultures from newborn...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Neonatal ischemia Synaptosome Neuronal plasticity Proteome Brain injury Ischemic perinatal stroke (IPS...

.... Neonatal Brain injury Hypothermia therapy Neurodegeneration Neuroprotection Hypoxic-ischemic encephalopathy Perinatal asphyxia National Institutes of Health (NIH) 10.13039/100000002 Therapeutic hypothermia has been the standard of clinical care for moderate-to-severe hypoxic...

... its impact on the acute evolution of preterm neonatal brain injury. We aimed to compare the effects of maternal BM in combination with mechanical ventilation on the white matter (WM) of late preterm sheep. At 0.85 of gestation, pregnant ewes were randomly assigned to receive intra-muscular (i.m...

...R. Ann Sheldon; Christine Windsor; Donna M. Ferriero Neonatal hypoxic-ischemic brain injury is commonly studied by means of the Vannucci procedure in mice or rats (unilateral common carotid artery occlusion followed by hypoxia). Previously, we modified the postnatal day 7 (P7) rat procedure for use...

... inflammation/chorioamnionitis are at high risk of brain injury and life-long neurological deficits. In this study, we assessed the efficacy of early intervention umbilical cord blood (UCB) cell therapy in a large animal model of preterm brain inflammation and injury. We hypothesised that UCB treatment would...

... hemispheric and hippocampal volumes were greater in the HI-BHB group than the HI-Veh group. However, the results of functional tests did not differ between both groups. Postischemic BHB administration reduced brain injury in suckling rats after HI. The safe clinical application of our animal model to human...

..., instructions or products referred to in the content or advertisements. 2017 Cerebellum Developing brain Erythropoietin Hypothermia therapy Immunohistochemistry Monkey Central nervous system Brain injury Hypoxic-ischemic encephalopathy NIH Intrapartum hypoxia is one important...

... hypothermia provides incomplete neuroprotection for neonatal hypoxic-ischemic encephalopathy (HIE). We examined whether hemodynamic goals that support autoregulation are associated with decreased brain injury and whether these relationships are affected by birth asphyxia or vary by anatomic region. Methods...

... and/or upregulate HIF-1α, and thereby mediate HI preconditioning protection [ 6 ]. One of the genes regulated by HIF-1α is erythropoietin (EPO). EPO has been shown to reduce cellular injury in vitro [ 7,8,9,10 ] and to reduce brain injury in in vivo models of neonatal stroke [ 11,12,13,14 ] and HI [ 15,16,17,18,19...

.... Injury to the developing white matter is a characteristic feature of human preterm brain injury. Data are accumulating, however, for neuronal injury in the developing cerebral cortex. In the most widely used rodent model of preterm HI brain injury, conflicting data have been reported regarding...

... than those in the controls when DFAT-CM was added 48 h prior to OGD. The treatment effect of adding DFAT-CM 24 h prior to OGD was also significant. Our results indicate that intravenous injection with DFAT cells is effective for ameliorating HI brain injury, possibly via paracrine effects. Fig. 2...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Brain injury Ovine model White matter Neuropathology Timing Intrauterine growth restriction Fetal growth restriction Cerebral palsy The neuropathology underlying...