...A. Andriulli; A. Arrigoni; T. Gindro; I. Karbowiak; G. Buzzetti; D. Armanini Plasma levels of canrenone and androgen receptor-active materials (ARM) were determined during long-term oral K-canrenoate or spironolactone therapy in cirrhotics with chronic recurrent ascites. Mean plasma canrenone level...

... patients with ascites were randomly allocated to receive for 2 weeks bumetanide (group A, n = 13), spironolactone (group B, n = 12) or a combination of the two drugs (group C, n = 12) after a 5-day stabilization period. The response to the treatment was 69, 42 and 83% in groups A, B and C, respectively...

... investigated. The dosage of spironolactone needed to induce a negative sodium balance correlated significantly with plasma aldosterone concentration: r = 0.64; p < 0.001. However, in cases with plasma albumin concentration < 3 g/dl, glomerular filtration rate < 80 ml/min, and plasma sodium...