... compared. RNA and protein expression levels of significantly upregulated neuropeptides were analyzed. Results: Of the neuropeptides associated with UC, somatostatin (SST) was significantly elevated in areas of remission, according to RNA sequencing results of mucus and expression levels in mucus RNA...

... perception. Recently, it has been revealed that dietary glutamate has many beneficial functions in the gastrointestinal tract. However, the precise mechanism of glutamate sensing still remains unclear. Using primary rat gastric mucosal cell cultures, we demonstrated that somatostatin-secreting D cells...

... given 25 μg/kg PGE 2 (p < 0.05). The total volume of gastrin/CCK-immunoreactive cells was higher in rats given 25 μg/kg PGE 2 or 50 μg/kg MePGE 2 than in controls (p < 0.05). The volume density of somatostatin-immunoreactive cells increased in rats given 5 μg/kg MePGE 2 , but the total volumes...

...Wolfgang E. Schmidt Digestion Digestion I997:58(suppl I ):56 58 woifgmigE. Schmu, Laboratory of Molecular Gastroenterology. 1st Department of Medicine. Christian Albrecht University of Kiel. Germany The intestine, an Endocrine Organ Key Words Cholecyslokinin Somatostatin Glucagon-like peptide 1...

...John DelValle Digestion Stomach and Duodenum Digestion I997;58(suppl 4-7 John Del Valle Department o f Internal Medicine, Division o f Gastroenterology, University o f Michigan Medical Center. Ann Arbor. Mich.. USA The Stomach as an Endocrine Organ Key Words Stomach Gastrin Somatostatin...

...F. Raulf; J. Pérez; D. Hoyer; C. Bruns Somatostatin regulates endocrine and exocrine secretion, acts as a neurotransmitter/neuro-modulator and possesses antiproliferative properties. These diverse physiological effects are mediated by G-protein coupled receptors of which at least five subtypes have...

...Keiko Shiratori; Shin-ichiro Watanabe; Tadashi Takeuchi We investigated the effect of indomethacin on secretin- and somatostatin-induced inhibition of gastric acid secretion stimulated by intravenous infusion of pentagastrin (0.3 µg/kg·h) in anesthetized rats. Intravenous administration...

... is a promising concept in the prevention of complications. The hormone somatostatin and its synthetic analogue octreotide have been shown to profoundly inhibit exocrine pancreatic secretion, particularly the secretion of proteases. In a randomized, placebo-controlled, multicenter double-blind trial we analyzed...

...Roger D. Hurst; Irvin M. Modlin Radiolabeled somatostatin analogs are potentially of considerable value in both the localization and treatment of somatostatin receptor-bearing tumors. Whole body 123 I-labeled Tyr 3 -octreotide scintigraphy is capable of detecting and localizing primary tumors...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 1993 Somatostatin Octreotide Short bowel syndrome Dumping syndrome M.J.G. Farthing Departments...

...John P. Cello; Mary F. Chan Somatostatin and its analogue, octreotide, produce dramatic decreases in splanchnic arterial blood flow and portal venous pressure while preserving cardiac output and systemic blood pressure. A limited number of prospective randomized clinical trials of somatostatin...

...P. Marbach; U. Briner; M. Lemaire; A. Schweitzer; T. Terasaki Somatostatin and its octapeptide analogue octreotide (Sandostatin®) have a similar high affinity for specific receptors with IC 50s in the sub-nanomolar range. Hence, the striking superiority of octreotide in vivo, which includes...

.... By contrast, insulinomas are more resistant to somatostatin agonist therapy. In the Zollinger-Ellison syndrome, octreotide is effective in alleviating symptoms and in reducing serum gastrin levels. However, its use in this syndrome has been superceded by omepra-zole. Radioiodine-labelled octreotide has been...

...M. Moroni; R. Esposito; M. Cernuschi; F. Franzetti; G.P. Carosi; G.P. Fiori We evaluated the effect of octreotide, a long-acting synthetic analogue of native somatostatin, on bowel frequency in 13 patients with AIDS-associated refractory diarrhoea. Cryptosporidium enteritis and cytomegalovirus...

...J.C. Reubi; E. Krenning; S.W.J. Lamberts; L. Kvols Somatostatin receptors (SS-R) have been identified in membrane homoge-nates or tissue sections from several hundred human tumors. SS-R have been found in most neuroendocrine tumors, i.e. GH- and TSH-producing pituitary tumors, endocrine...

...S.W.J Lamberts; J.A. Chayvialle; E.P. Krenning In this review, we evaluate radiological techniques currently used to localize gastroenteropancreatic (GEP) endocrine tumors. We also describe the visualization, using intravenous administration of two isotope-labelled somatostatin analogs ( 123 -I-Tyr...

...E.P. Krenning; D.J. Kwekkeboom; H.Y. Oei; R.J.B. de Jong; F.J. Dop; W.W. de Herder; J.C. Reubi; S.W.J. Lamberts High numbers of high-affinity somatostatin binding sites have been found on carcinoid tumors, gastrinomas, small cell lung cancers and the majority of medullary thyroid cancers, enabling...

...Hiroshi Ishiguro; Tetsuo Hayakawa; Takaharu Kondo; Tokimune Shibata; Motoji Kitagawa; Yuzo Sakai; Hiroshi Sobajima; Yasuyuki Nakae; Makoto Tanikawa To clarify whether somatostatin has an inhibitory effect on pancreatic acinar cells, we studied the effect of a long-acting analogue of somatostatin...

...Axel Holstege; Klaus-Dieter Palitzsch; Jürgen Schölmerich Pharmacological management of acute variceal hemorrhage appears to be effective in patients with liver cirrhosis. Somatostatin and presumably its longer-acting analog, octreotide, are more efficient and safer than other vasoconstrictors like...

...M. Ebert; H. Friess; H.G. Beger; M.W. Büchler Prognosis in patients with advanced pancreatic cancer is dismal. There has been no effective therapy for these patients so far. Somatostatin and its analogues have been proven to be potent inhibitors of experimental pancreatic cancer. Tumor inhibition...