... to achieve sedation in patients undergoing colonoscopies. Methods: This multicenter, double-blind, placebo-controlled, phase III investigator-initiated trial included patients who underwent colonoscopy under sedation with remimazolam (initial dose: 3 mg; additional dose: 1 mg) or normal saline (placebo...

... neuroleptanalgesia (m-NLA) with midazolam is often used for sedation and analgesia during endoscopic submucosal dissection (ESD) for gastrointestinal neoplasia. However, interruption due to poor response to midazolam is often experienced during ESD for esophageal squamous cell carcinoma (ESCC) because most patients...

... of esophageal varices (EVs). However, repeated sedation in endoscopic treatment has the risk of prolonging hepatic encephalopathy and affects the respiratory state of liver cirrhosis (LC) patients, in whom pulmonary arteriovenous shunts are observed. We evaluated prospectively whether transnasal endoscopic APC...

...Philippe Van der Linden Sedation is required to treat an ever increasing number of patients for medical diagnostic or therapeutic procedures, in particular in gastrointestinal endoscopy. Due to the apparent ease of administration of sedative techniques, and due to the shortage of anesthetic staff...

...N. Hofmann; C. Datz; H. Schöchl High-fidelity simulation uses simulators that combine all of the physiological and pharmacological responses of a human in a manikin. These simulators change and respond to the users and trainees. Using simulators for teaching sedation in the field...

...G.A. Paspatis; G. Tribonias; K. Paraskeva Sedation and analgesia is the standard of care during diagnostic and therapeutic endoscopic gastrointestinal procedures in most areas of the world. Unsedated endoscopy is feasible in selected patients, but requires commitment on the part of both the patient...

...David J. Bjorkman There is general consensus in national and societal guidelines that training for sedation should be part of basic training for endoscopy. There is no clear consensus, however, on the structure of that training. More importantly, these same guidelines are often silent...

...Anthony T.R. Axon Digestive endoscopy covers a wide variety of procedures; the need for sedation is governed by the invasiveness and length of the procedure, the wishes of the patient, the desire of the operator for a compliant patient, and safety. Many patients are prepared to undergo upper...

...Till Wehrmann It has been demonstrated that a processed EEG derivative may reflect the patient’s level of consciousness during endoscopic sedation. However, to date a clinical benefit of EEG monitoring with respect to relevant safety parameters in routine gastrointestinal endoscopy has not been...

.... Although there are no studies comparing the safety and efficacy of propofol administration by anesthesiologists versus non-anesthesiologists for sedation during endoscopy, there is strong evidence that propofol administration by non-anesthesiologists is safe and efficacious for the majority of patients...

...Spiros D. Ladas; Yoshiharu Satake; Ibrahim Mostafa; John Morse Gastroscopy and colonoscopy are standard practice for diagnosing upper gastrointestinal and colonic diseases. Sedation improves tolerance of the endoscopic procedures, but may be responsible for about 50% of the complication rate...

...Akira Horiuchi; Yoshiko Nakayama; Yoshihiko Katsuyama; Shigeru Ohmori; Yasuyuki Ichise; Naoki Tanaka Background and Aim: Automobile driving is prohibited after midazolam sedation because of the slow recovery of psychomotor function. This study prospectively assessed the safety of low-dose propofol...

...Akira Horiuchi; Yoshiko Nakayama; Naoki Tanaka; Yasuyuki Ichise; Yoshihiko Katsuyama; Shigeru Ohmori Background and Aim: There are only a few studies on propofol sedation for very elderly patients. The present study was undertaken to evaluate the safety of propofol sedation in patients 90 years...

... by comparing the results of the combined sensor with arterial blood gas measurements. In an observational part, monitoring data were obtained from 25 patients undergoing colonoscopy, sedated with midazolam and alfentanil and from 8 patients without sedation. Results: There was an excellent correlation between...