... University Hospital, Lund, Sweden Cholecystokinin Increases Small Intestinal Motility and Reduces Enteric Bacterial Overgrowth and Translocation in Rats with Surgically Induced Acute Liver Failure Key Words Cholecystokinin Bacterial overgrowth Translocation Motility Hepatectomy Acute liver failure Intestine...

...K. Takeuchi; S. Kato; K. Takehara; Y. Asada; T. Yasuhiro The role of nitric oxide (NO) in the gastric mucosal blood flow response and the healing of HCl-induced gastric lesions was investigated in rats. After 18 h fasting rats were given 0.6 N HCl p.o. for the induction of gastric lesions, and 1 h...

...K. Takeuchi; K. Takehara; T. Ohuchi We examined the effect of diethyldithiocarbamate (DDC), the superoxide dismutase (SOD) inhibitor, on the development of gastric lesions induced by indomethacin in rats. Indomethacin (25 mg/kg) was given subcutaneously, and gastric acid secretion, motility, lipid...

... indicate that: (1) CCK is involved in the pancreatic adaptive response after BPB in rats, and (2) in the context of a protein malnutrition state, CCK dissociates its pancreatic growth and enzymatic effects, favouring the former. 2 04 1993 22 10 1993 1 07 1994 © 1994 S. Karger AG...

...W. Fries; D. Giacomin; M. Plebani; A. Martin The influence of experimental colitis, induced by trinitrobenzenesulphonic acid with ethanol, on bone mineralisation and mineral metabolism was investigated in male rats. Three days after colitis induction, there was a significant rise (p < 0.01...

... intraductal infusion of very low concentrations of glycodeoxycholic acid with intravenous caerulein. This study evaluates late histopathologic changes and gross complications in this pancreatitis model compared to the traditionally used high-dose bile salt model in rats. After 14 days, histopathologic...

...C. Blandizzi; G. Gherardi; C. Marveggio; G. Natale; D. Carignani; M. Del Tacca In the present study, the protective effect of omeprazole on gastric mucosa injury induced by ethanol •HCl in rats and the putative mechanisms involved in this action were investigated. Misoprostol and ranitidine were...

...I. Zahavi; Z. Burg; H. Marcus; F. Karmeli; M. Nusinovitz; G. Dinari Colloid bismuth subcitrate (CBS) has a protective effect on ulcerated gastric and duodenal mucosa. To investigate its effect on large intestinal mucosal injury, we used acetic acid-induced colitis in the rat. Colitis was produced...

...K. Takeuchi; M. Okada; K. Ueshima; T. Ohuchi; S. Okabe The role of endogenous sulfhydryls (SH) in the healing of HCl-induced gastric injury was investigated in the rat. The animals fasted for 18 h were given 1 ml of 0.6 N HCI by gavage, and they were fed normally from 1 h later and killed various...

...Giuseppina Morini; Daniela Grandi; Giulio Bertaccini This study examined the gastroprotective effect of (R)-α-methylhistamine (MHA), a selective agonist of histamine H 3 receptors. Gastric lesions were induced in the rat by administering absolute ethanol in a volume of 1 ml. Stomachs were removed 1...

...S. Bardócz; G. Grant; D.S. Brown; S.W.B. Ewen; J.C. Stewart; A. Pusztai Fasting reduced the weight, protein, DNA, RNA and polyamine contents of the small intestine of rats, but its effects on the in vivo uptake of intraperitoneally injected 14 C-spermidine through the basolateral membrane...

...Renata Fabia; Aamer Ar’Rajab; Roger Wïllén; Roland Andersson; Bo Ahrén; Käre Larsson; Stig Bengmark The therapeutic effects of exogenous phosphatidylcholine and phosphatidylinositol on acetic acid-induced colitis in rats were evaluated. A uniform colitis developed 4 days after instillation of 4...

...Johanna Schmidtler; Wolfgang Schepp; Volker Schusdziarra; Meinhard Classen We investigated the hypothesis of a direct effect of amino acids on gastric parietal cells. [ 14 C]aminopyrine uptake into isolated enriched rat parietal cells served as a quantitative index of H + production. Cells were...

...A. Pusztai; S.W.B. Ewen; G. Grant; W.J. Peumans; E.J.M. van Damme; L. Rubio; S. Bardocz The effects on the small intestine and the growth of rats of six pure plant lectins: PHA ( Phaseolus vulgaris ); SBL ( Glycine maxima ); SNA-I and SNA-II ( Sambucus nigra ); GNA ( Galanthus nivalis ) and VFL...

...S. Bardócz; G. Grant; D.S. Brown; S.W.B. Ewen; I. Nevison; A. Pusztai Kidney bean lectin, PHA, stimulated the hyperplastic and hypertrophic growth of rat small intestine. This growth was preceded by a rapid accumulation of polyamines in the small intestine. However, since the lectin had little...

...Koji Takeuchi; Hideyuki Nishiwaki; Hideyuki Osano; Satomi Ebara; Susumu Okabe We investigated the relationship between the severity of acute injury and the rapidity of mucosal repair in stomachs of anesthetized rats, and examined the influence of prostaglandins (PGs) on the process of restoration...

... effect of sucralfate against indomethacin-induced intestinal ulceration in the rat. Sucralfate was found to possess a marked protective effect on the intestinal mucosa (ulcer index 23.16 ± 6.58 vs. 225 ± 36.37; p < 0.001). Sucralfate elevated basal mucosal prostaglandin E 2 generation (p < 0.001...

...Gábor Varga; Miklós Papp; István Dobronyi; Carmelo Scarpignato The effect of equimolar doses (6 nmol/kg) of bombesin and its mammalian counterpart, GRP, on pancreatic growth and secretion was studied in adult rats. Both peptides were administered intraperitoneally three times a day for 5...

...K. Takeuchi; M. Okada; H. Niida; S. Okabe Healing of duodenal ulcers induced by indomethacin + histamine was investigated in rats. Animals were treated with indomethacin (5 mg/kg, s.c, once daily) and histamine (40 mg/kg, s.c, 3 times every 2.5 h after indomethacin treatment) for 2 days under...

... haemodynamcis in the cirrhotic rat. Portal pressure (PP), wedged hepatic venous pressure (WHVP), portal venous flow (PVF), liver blood flow (LBF) and systemic blood pressure were measured in rats with dimethylnitrosamine-induced cirrhosis. Somatostatin was administered as a rapid injection, a continuous...