...Tomoko Kitajima; Takashi Yamaguchi; Kazuhiro Tani; Yoshitsugu Kubota; Masaru Okuhira; Kyoichi Inoue; Hisao Yamada The current study was designed to investigate the role of two potent vasoactive substances, endothelin (ET) and platelet-activating factor (PAF), in the pathogenesis of indomethacin...

...Bengt Kald; Gunnar Olaison; Rune Sjödahl; Christer Tagesson Intestinal mucosal content of platelet-activating factor (PAF-acether) was investigated in Crohn’s disease. The PAF-acether content was determined in mucosal biopsies from the ileum and colon in Crohn patients (n = 13), and in normal...

... was attenuated to some extent by the pretreatment with platelet-activating factor (PAF) inhibitor, CV-6209, superoxide dismutase plus catalase or the calcium antagonist, nicorandil. All these inhibitors significantly prevented the endothe-lin-1 -induced ischemic necrotic damage in the small intestine...

... that substance P acting via neurokinin-1 (NK1) receptors, chemokines interacting with CCR1 receptors and platelet activating factor play an important pro-inflammatory role in regulating the severity of pancreatitis and associated lung injury. On the other hand, complement factor 5a (C5a) acts as an anti...

... bradykinin, complement, nitric oxide (NO), and platelet-activating factor (PAF) become apparent. Essentially all of the mediators produced during pancreatitis are induced into production by inflammatory cytokines, or play an active role in initiating or amplifying the cytokine cascade. Oxygen intermediates...