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Keywords: Octreotide
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Journal Articles
Subject Area:
Gastroenterology
Journal: Digestion
Digestion (1996) 57 (Suppl. 1): 103–106.
Published Online: 05 February 2009
... minimal side effects. Beta-blockers are effective in preventing the first variceal haemorrhage and are well tolerated. Vasopressin tGLVP Variceal bleeding Safety Efficacy Survival Isosorbide-5-mononitrate Propranolol Somatostatin Octreotide Digestion Digestive Diseases Digestion 1996;57...
Journal Articles
Subject Area:
Gastroenterology
Journal: Digestion
Digestion (1996) 57 (Suppl. 1): 97–102.
Published Online: 05 February 2009
...H. Friess; M.W. Büchler Major pancreatic resection is still accompanied by considerable morbidity (35%) and mortality (10%). Typical complications, such as pancreatic fistula and abscess, are chiefly associated with exocrine pancreatic secretion. The hormone somatostatin and its analogue octreotide...
Journal Articles
Subject Area:
Gastroenterology
Journal: Digestion
Digestion (1996) 57 (Suppl. 1): 81–83.
Published Online: 05 February 2009
... profile of somatostatin analogues is better but patients must take frequent injections and may have bile problems. We combined IFN-α and octreotide treatment in 24 patients with malignant carcinoid tumours who did not respond biochemically to high-dose (300 μg/day) octreotide alone. Biochemical response...
Journal Articles
Subject Area:
Gastroenterology
Journal: Digestion
Digestion (1996) 57 (Suppl. 1): 36–37.
Published Online: 05 February 2009
..., and 4 other non-medullary thyroid cancer patients all received an intravenous bolus injection of 220 MBq [ 111 In-DTPA- D -Phe 1 ]octreotide. Planar anterior and posterior n camera images of head-neck, chest and abdomen were obtained 24 and 48 h after injection. All primary cancers showed [ 111 ln-DTPA...
Journal Articles
Subject Area:
Gastroenterology
Journal: Digestion
Digestion (1996) 57 (Suppl. 1): 22–28.
Published Online: 05 February 2009
...G. Weckbecker; F. Raulf; L. Tolcsvai; C. Bruns The somatostatin analogue octreotide (SMS 201-995) exerts potent anti-proliferative effects in a number of experimental cancer models. Here we report on the inhibitory effect of octreotide in combination with the chemothera-peutic agents mitomycin C...
Journal Articles
Subject Area:
Gastroenterology
Journal: Digestion
Digestion (1996) 57 (Suppl. 1): 93.
Published Online: 05 February 2009
...Lucio Gullo Subcutaneous injection of 50 μg octreotide before a meal can almost totally prevent the increase in exocrine pancreatic secretions caused by the meal. Octreotide inhibits plasma amino acid uptake by pancreatic acinar cells, and thus synthesis of pancreatic enzymes. This effect has...
Journal Articles
Subject Area:
Gastroenterology
Journal: Digestion
Digestion (1996) 57 (Suppl. 1): 38–41.
Published Online: 05 February 2009
... neuroblastoma, meningioma, low-grade astrocytoma and medulloblastoma express somatostatin receptors and can be imaged effectively using 111 In-octreotide. In addition to improved imaging techniques, somatostatin analogues are being developed for use in radiorecep-tor-guided surgery, as a component of adjuvant...
Journal Articles
Subject Area:
Gastroenterology
Journal: Digestion
Digestion (1996) 57 (Suppl. 1): 107–113.
Published Online: 05 February 2009
...Michael J.G. Farthing Octreotide inhibits intestinal motility and secretions of the gastro-intestinal tract and pancreas and mediators of diarrhoea and so is very useful in managing refractory diarrhoea. It is safe and effective in 75-80% of the 10-20% of cancer chemotherapy patients who develop...
Journal Articles
Subject Area:
Gastroenterology
Journal: Digestion
Digestion (1996) 57 (Suppl. 1): 7–10.
Published Online: 05 February 2009
...) of sst expression might improve the uptake of radioligand in in vivo scintigraphy of human sst-positive tumours, as well as the potential success of radiotherapy using radiolabelled SRIF analogues. In clonal pituitary cell lines, agonist exposure (SRIF-14, SRIF-28, octreotide) has been shown to either...
Journal Articles
Subject Area:
Gastroenterology
Journal: Digestion
Digestion (1996) 57 (Suppl. 1): 86–87.
Published Online: 05 February 2009
... after 69 ± 6.2 months of follow-up. Subclinical disease was diagnosed in 7/14 patients using somatostatin receptor scintigraphy; subsequent re-exploration of 6 led to scintigraphically proven cure in 5. 40 patients with bilobar hepatic disease underwent embolisation in combination with octreotide...
Journal Articles
Subject Area:
Gastroenterology
Journal: Digestion
Digestion (1996) 57 (Suppl. 1): 94–96.
Published Online: 05 February 2009
... of closures achieved, but also on their time and cost. The combined use of parenteral nutrition (TPN) and somatostatin inhibits pancreatic secretion well; no therapy can inhibit it completely. Presumptive use of octreotide, a subcutaneous formulation of somatostatin, in patients undergoing elective pancreatic...
Journal Articles
Subject Area:
Gastroenterology
Journal: Digestion
Digestion (1996) 57 (Suppl. 1): 88–89.
Published Online: 05 February 2009
...Håkan Ahlman We evaluated a hand-held scintillation detector for intra-operative localisation of somatostatin-receptor-positive tumours in situ, and after excision, as an addition to preoperative scintigraphy with [ 111 In-DTPA-Phe 1 ]octreotide. Using the hand-held detector, the suspect tumour...
Journal Articles
Subject Area:
Gastroenterology
Journal: Digestion
Digestion (1996) 57 (Suppl. 1): 2–6.
Published Online: 05 February 2009
... the Golgi apparatus, lysosomes and secretory granules. We have found that mouse AtT20 and primary cultures of human growth-hormone-secreting pituitary adenoma cells internalised a high amount of radio-iodinated [Tyr 3 ]octreotide. Since octreotide binds with high affinity to the sst 5 and ssts subtypes...
Journal Articles
Subject Area:
Gastroenterology
Journal: Digestion
Digestion (1996) 57 (Suppl. 1): 84–85.
Published Online: 05 February 2009
..., instructions or products referred to in the content or advertisements. 1996 Somatostatin Neuroendocrine Combination Lanreotide Tumour Diarrhoea Serotonin Octreotide Metastases Interferon-α Digestion Neuroendocrine GEP Tumors Digestion 1996;57(suppl l):84-85 5. Faiss II...
Journal Articles
Subject Area:
Gastroenterology
Journal: Digestion
Digestion (1996) 57 (Suppl. 1): 57–61.
Published Online: 05 February 2009
... the most somatostatin receptors in vitro and their metastases are somatostatin receptor positive in vitro, so that [ 111 In-DTPA- D -Phe 1 ]octreotide (OCT) can be used to image them. OCT was compared with conventional imaging techniques (CON) in a European Multicentre Trial. In 350 evaluable patients, CON...
Journal Articles
Subject Area:
Gastroenterology
Journal: Digestion
Digestion (1996) 57 (Suppl. 1): 62–68.
Published Online: 05 February 2009
...C.S. Thompson; T.M. O’Dorisio; E.A. Woltering Excessive secretion of peptides causes the clinical syndromes associated with functional gastro-intestinal tumours. The somatostatin analogue octreotide acetate inhibits peptide release from a variety of tumours. This study investigated the interactions...
Journal Articles
Subject Area:
Gastroenterology
Journal: Digestion
Digestion (1996) 57 (Suppl. 1): 15–16.
Published Online: 05 February 2009
..., and octreotide can be considered a useful therapeutic tool to control gastrin-driven ECL cell growth in humans. © 1996 S. Karger AG, Basel Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any...
Journal Articles
Subject Area:
Gastroenterology
Journal: Digestion
Digestion (1996) 57 (Suppl. 1): 69–71.
Published Online: 05 February 2009
.... 1996 Gastro-enteropancreatic tumours Octreotide Interferons Chemotherapy Digestion Neuroendocrine GEP Tum ors Digestion 1996;57(suppl 1):69 7 1 R. Arnold M. Frank Department of Internal Medicine. Philipps University, Marburg, Germany Control of Growth in Neuroendocrine Gastro...
Journal Articles
Subject Area:
Gastroenterology
Journal: Digestion
Digestion (1996) 57 (Suppl. 1): 17–21.
Published Online: 05 February 2009
...B. Stolz; P. Smith-Jones; R. Albert; L. Tolcsvai; U. Briner; G. Ruser; H. Mäcke; G. Weckbecker; C. Bruns The aim of the present study was to selectively target a β-emitter-labelled octreotide analogue to somatostatin (SRIF)-receptor-expressing tumours and to evaluate the feasibility of SRIF...
Journal Articles
Subject Area:
Gastroenterology
Journal: Digestion
Digestion (1996) 57 (Suppl. 1): 72–76.
Published Online: 05 February 2009
.... For surgically untreatable NE neoplasms, the therapeutic approach remains undefined. Somatostatin analogues, particularly octreotide, can control the clinical effects of hormone overproduction in NE neoplasms and they have revolutionised individualised treatment, particularly for biologically active tumours. So...