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1-7 of 7
Keywords: NSAIDs
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Journal Articles
Alterations of Canalicular ATP-Binding Cassette Transporter Expression in Drug-Induced Liver Injury
Available to PurchaseSubject Area:
Gastroenterology
Journal:
Digestion
Digestion (2014) 90 (2): 81–88.
Published Online: 04 September 2014
... with necroinflammatory hepatocellular injury (most frequently caused by NSAIDs), transporter staining was normal in areas where hepatocyte morphology was preserved. Due to hepatocyte necrosis and the reduction of the hepatocyte number, overall transporter expression was reduced without a reduction in transporter...
Journal Articles
NSAIDs and Acidic Environment Induce Gastric Mucosal Cellular Mitochondrial Dysfunction
Available to PurchaseSubject Area:
Gastroenterology
Yumiko Nagano, Hirofumi Matsui, Masato Tamura, Osamu Shimokawa, Yukio Nakamura, Tsuyoshi Kaneko, Ichinosuke Hyodo
Journal:
Digestion
Digestion (2012) 85 (2): 131–135.
Published Online: 19 January 2012
...Yumiko Nagano; Hirofumi Matsui; Masato Tamura; Osamu Shimokawa; Yukio Nakamura; Tsuyoshi Kaneko; Ichinosuke Hyodo Non-steroidal anti-inflammatory drugs (NSAIDs) often cause gastrointestinal complications such as gastric ulcers and erosions. Recent studies on the pathogenesis have revealed...
Journal Articles
Geranylgeranylacetone Protects against Diclofenac-Induced Gastric and Small Intestinal Mucosal Injuries in Healthy Subjects: A Prospective Randomized Placebo-Controlled Double-Blind Cross-Over Study
Available to PurchaseSubject Area:
Gastroenterology
Yasumasa Niwa, Masanao Nakamura, Ryoji Miyahara, Naoki Ohmiya, Osamu Watanabe, Takafumi Ando, Hiroki Kawashima, Akihiro Itoh, Yoshiki Hirooka, Hidemi Goto
Journal:
Digestion
Digestion (2009) 80 (4): 260–266.
Published Online: 16 October 2009
...-steroidal anti-inflammatory drugs (NSAIDs). We planned a pilot study to investigate the protective effects of geranylgeranylacetone (GGA) against NSAID-induced small intestinal injuries using video capsule endoscopy (VCE). Subjects and Methods: Ten healthy male volunteers took oral GGA 300 mg/day (regimen...
Journal Articles
Non-Steroidal Anti-Inflammatory Drugs Inhibit the Processes of Mucosal Cell Proliferation Associated with Duodenal Ulcer Healing
Available to PurchaseSubject Area:
Gastroenterology
Journal:
Digestion
Digestion (1992) 53 (3-4): 129–133.
Published Online: 04 February 2009
...S. Levi; R.A. Goodlad; C.Y. Lee; G. Stamp; M.J. Walport; N.A. Wright; H.J.F. Hodgson We demonstrate that, in patients taking non-steroidal anti-inflammatory drugs (NSAIDs), there is inhibition of the proliferation of mucosal cells that normally leads to healing of duodenal ulcers. A microdissection...
Journal Articles
Microbial Flora in NSAID-Induced Intestinal Damage: A Role for Antibiotics?
Available to PurchaseSubject Area:
Gastroenterology
Journal:
Digestion
Digestion (2006) 73 (Suppl. 1): 136–150.
Published Online: 27 February 2006
...Ángel Lanas; Carmelo Scarpignato Upper gastrointestinal (GI) complications are well-recognized adverse events associated with non-steroidal anti-inflammatory drug (NSAID) use. However, NSAID-induced damage to the distal GI tract is also common and more frequent than previously recognized...
Journal Articles
Challenges in Managing NSAID-Associated Gastrointestinal Tract Injury
Available to PurchaseSubject Area:
Gastroenterology
Journal:
Digestion
Digestion (2004) 69 (Suppl. 1): 25–33.
Published Online: 10 March 2004
...Jay L. Goldstein The use of non-selective non-steroidal anti-inflammatory drugs (NSAIDs) and/or aspirin is associated with upper gastrointestinal (UGI) tract injury, particularly in high-risk patients (e.g. those with prior upper GI ulcers and ulcer complications, individuals ≧ 65 years, or those...
Journal Articles
Health Care Resource Utilization and Costs of NSAID-Induced Gastrointestinal Toxicity: A Population-Based Study in Switzerland
Available to PurchaseSubject Area:
Gastroenterology
Journal:
Digestion
Digestion (2004) 69 (1): 10–19.
Published Online: 10 March 2004
...Fabiola Delcò; Pierre Michetti; Christoph Beglinger; Michael Fried; Thomas D. Szucs Background and Aims: The well-recognized gastrointestinal toxicity of NSAIDs ranges from mild symptoms to severe complications requiring medical attention and leading to work loss. The present study evaluates...