... that NSAIDs induce lipid peroxidation in gastric epithelial cells by generating superoxide in mitochondria, independently with cyclooxygenase inhibition and the subsequent prostaglandin deficiency. More recently, gastric hydrochloric acid (HCl) has been regarded as an inciting factor of gastric mucosal...

.... These ulcers resemble human gastric ulcers that penetrate the muscularis mucosa. The involvement of oxygen radical-mediated lipid peroxidation as the cause of these ulcers was investigated. With ferrous iron or ascorbic acid alone, gastric ulcers did not form, whereas penetrating ulcers were produced...

...Keiji Nishida; Yoshiji Ohta; Takashi Kobayashi; Isao Ishiguro In rats subjected to water immersion restraint (WIR) stress for 1, 3, and 6 h, gastric mucosal lesions developed time-dependently with an increase in lipid peroxide (LPO) levels and a decrease in nonprotein sulfhydryl levels...

... Inflammatory bowel disease Trinitrobenzene-sulfonic acid Colitis Z-103 Antioxidative activity Lipid peroxidation Digestion Original Paper Digestion 1997;58:464-468 Received: April 25, 1995 Accepted: February 4. 1997 Toshikazu Yoshikawa Taiji Yamagiichi Norimasa Yoshida Hirofumi Yamamoto Seiji Kitazumi...

...K. Takeuchi; K. Ueshima; Y. Hironaka; Y. Fujioka; J. Matsumoto; S. Okabe The relationship of gastric hypermotility to mucosal hemodynamics, lipid peroxidation and vascular permeability changes was investigated in the pathogenesis of indomethacin-induced gastric lesions in rats. Subcutaneous...

.... 1999 Alcoholic pancreatic injury Adenosine triphosphate Glutathione Lipid peroxidation Mitochondria Protein oxidation The mechanisms underlying chronic ethanol (ETOH) injury to the pancreas are not completely known. There is evidence suggesting that ETOH toxicity in the pancreas...

... in significant oxidative modification of proteins in pancreatic homogenates as compared to saline-injected controls (p < 0.01). Repeated injections of the secretagogue were unable to induce a further increase in modified proteins. Protein oxidation preceded the formation of the lipid peroxidation product...

..., instructions or products referred to in the content or advertisements. 1998 Acute pancreatitis Rat pancreatic acinar cells Oxidative stress Lipid peroxidation Cytosolic calcium Energy metabolism Original Paper Digestion 1998;59:175 185 Received: July 10, 1997 Accepted: December 15, 1997 H...